The recent interest in the clinical applications of Piloty's acid derivatives as HNO donors for the treatment of cardiovascular system dysfunction has led us to the examination of factors controlling HNO release from selected ortho-substituted N-hydroxysulfonamides. Here we present the kinetic and quantum mechanical studies on the mechanism of HNO release from selected ortho-substituted N-hydroxysulfonamides and in vivo examination of the antiaggregatory properties of N-hydroxy-(2-bromobenzene)sulfonamide complex with sodium salt of β-cyclodextrin sulfobutyl ethers-ethyl ethers as compared with Angeli's salt.

中文翻译：

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Piloty酸衍生物的分解–有助于理解控制HNO释放的因素

最近对于将Piloty酸衍生物作为HNO供体用于治疗心血管系统功能障碍的临床应用的兴趣使我们研究了控制从选定的邻位取代N-羟基磺酰胺中释放HNO的因素。在这里，我们介绍动力学和量子力学研究从选定的邻位取代的N-羟基磺酰胺中释放出HNO的机理，以及体内研究β-环糊精钠盐对N-羟基-（2-溴苯）磺酰胺配合物的抗聚集性能。 与安吉利盐相比的磺基丁基醚-乙基醚。