The first total synthesis of kukoamine B bimesylate was completed from 1,4-diaminobutane dihydrochloride in 12 steps with a 11.4% overall yield, and all the steps could be carried out at a kilogram scale. The cyano groups were used as the precursor of amino groups to avoid the competitive reaction delicately. The aza-Michael addition reaction, amidation and hydrogenation of the cyano group sequence was streamlined as a general approach towards the synthesis of polyamine structures.

中文翻译：

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精胺生物碱库克胺双甲磺酸盐的全合成

首次以1,4-二氨基丁烷二盐酸盐为原料合成kukoamine B二甲磺酸盐，共分12步，总收率11.4%，所有步骤均可在公斤级规模进行。氰基被用作氨基的前体，以避免微妙的竞争反应。氮杂-迈克尔加成反应、氰基序列的酰胺化和氢化被简化为合成多胺结构的一般方法。