Mussel‐Inspired Contact‐Active Antibacterial Hydrogel with High Cell Affinity, Toughness, and Recoverability,Advanced Functional Materials

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Mussel‐Inspired Contact‐Active Antibacterial Hydrogel with High Cell Affinity, Toughness, and Recoverability
Advanced Functional Materials ( IF 18.5 ) Pub Date : 2018-11-13 , DOI: 10.1002/adfm.201805964
Donglin Gan ₁ , Tong Xu ₁ , Wensi Xing ₁ , Xiang Ge ₂ , Liming Fang ₃ , Kefeng Wang ₄ , Fuzeng Ren ₅ , Xiong Lu ₁

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Antibacterial hydrogel has received extensive attention in soft tissue repair, especially preventing infections those associated with impaired wound healing. However, it is challenging in developing an inherent antibacterial hydrogel integrating with excellent cell affinity and superior mechanical properties. Inspired by the mussel adhesion chemistry, a contact‐active antibacterial hydrogel is proposed by copolymerization of methacrylamide dopamine (MADA) and 2‐(dimethylamino)ethyl methacrylate and forming an interpenetrated network with quaternized chitosan. The reactive catechol groups of MADA endow the hydrogel with contact intensified bactericidal activity, because it increases the exposure of bacterial cells to the positively charged groups of the hydrogel and strengthens the bactericidal effect. MADA also maintains the good adhesion of fibroblasts to the hydrogel. Moreover, the hybrid chemical and physical cross‐links inner the hydrogel network makes the hydrogel strong and tough with good recoverability. In vitro and in vivo tests demonstrate that this tough and contact‐active antibacterial hydrogel is a promising material to fulfill the dual functions of promoting tissue regeneration and preventing bacterial infection for wound‐healing applications.

中文翻译：

贻贝启发的接触活性抗菌水凝胶，具有高细胞亲和力，韧性和可回收性

抗菌水凝胶已在软组织修复中受到广泛关注，尤其是预防与伤口愈合不良有关的感染。然而，在开发具有优异的细胞亲和力和优异的机械性能的内在的抗菌水凝胶方面具有挑战性。受到贻贝粘附化学的启发，通过使甲基丙烯酰胺多巴胺（MADA）与甲基丙烯酸2-（二甲氨基）乙酯共聚并与季铵化壳聚糖形成互穿网络，提出了一种接触活性抗菌水凝胶。MADA的反应性邻苯二酚基团使水凝胶具有接触增强的杀菌活性，因为它增加了细菌细胞对水凝胶带正电基团的暴露并增强了杀菌效果。MADA还保持了成纤维细胞与水凝胶的良好粘合。此外，水凝胶网络内部的化学和物理混合交联键使水凝胶坚韧而具有良好的可回收性。体外和体内试验表明，这种坚韧且具有接触活性的抗菌水凝胶是一种有前途的材料，可实现促进组织再生和防止细菌感染的双重功能，以治疗伤口。

更新日期：2018-11-13

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