A robust, safe, and scalable process for the synthesis of 4,6-dichloropyrimidine-5-carbonitrile is described. All of the intermediates in the process are storable under normal conditions. Significant process safety evaluation was undertaken in this route, and the highlights of these studies are presented. This scalable and safe synthetic strategy can be applied for multikilogram-scale production.

中文翻译：

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合成4,6-二氯嘧啶-5-腈的另一种可扩展方法

描述了用于合成4，6-二氯嘧啶-5-腈的鲁棒，安全且可扩展的方法。在正常条件下，该过程中的所有中间体均可存储。在此途径中进行了重要的过程安全性评估，并介绍了这些研究的重点。这种可扩展且安全的合成策略可用于多千克规模的生产。