An Alternative Scalable Process for the Synthesis of 4,6-Dichloropyrimidine-5-carbonitrile,Organic Process Research & Development

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An Alternative Scalable Process for the Synthesis of 4,6-Dichloropyrimidine-5-carbonitrile
Organic Process Research & Development ( IF 3.1 ) Pub Date : 2018-11-13 00:00:00 , DOI: 10.1021/acs.oprd.8b00154
Bin Zhang ₁ , Huixin Yan ₁ , Chongfeng Ge ₁ , Bo Liu ₁ , Zhenping Wu ₁

Affiliation

A robust, safe, and scalable process for the synthesis of 4,6-dichloropyrimidine-5-carbonitrile is described. All of the intermediates in the process are storable under normal conditions. Significant process safety evaluation was undertaken in this route, and the highlights of these studies are presented. This scalable and safe synthetic strategy can be applied for multikilogram-scale production.

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