Local molecular environment governs material interface properties, especially the substrate’s exposing behavior and overall functionality expression. Although current techniques can provide efficient surface property modification, challenges in molecule spatial distribution and composition controls limited the generation of homogeneous and finely tunable molecular environment. In this study, Au–thiolate rupturing operation in chemical lift-off lithography (CLL) is used to manipulate the substrate interface molecular environment. The creation of randomly distributed artificial self-assembled monolayer defects generates vacancies for substrate property modification through back-insertion of molecules with opposite functionalities. Surface wettability adjustment is utilized as an example, where well-controllable molecule distribution provides finely tunable substrate affinity toward liquids with different physical properties. The distinct property difference between two surface regions assists microdroplet formation when liquids flow through, not only water solution but also low-surface-tension organic liquids. These microdroplet arrays become a template to guide material assembly in its formation process and act as pH-sensitive platforms for high-throughput detection. Furthermore, the tunability of the molecular pattern in this approach helps minimize the coffee-ring effect and the sweet-spot issue in matrix-assisted laser desorption/ionization mass spectrometry. Two-dimensional molecular manipulation in the CLL operation, therefore, holds the capability toward controlling homogeneous material surface property and toward exhibiting behavior adjustments.

中文翻译：

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通过二维分子处理可精细调节表面润湿性

局部分子环境控制着材料的界面特性，尤其是基材的暴露行为和整体功能表达。尽管当前的技术可以提供有效的表面性质修饰，但是分子空间分布和组成控制方面的挑战限制了均质和可微调分子环境的产生。在这项研究中，使用化学剥离平版印刷术（CLL）进行金-硫醇盐的破裂操作来控制基底界面分子环境。随机分布的人工自组装单层缺陷的产生会通过反向插入具有相反功能的分子而产生空位，从而改变底物的性质。以表面润湿性调节为例，其中可控的分子分布为具有不同物理性质的液体提供了可微调的底物亲和力。当液体不仅流过水溶液而且流过低表面张力的有机液体时，两个表面区域之间明显的特性差异有助于微滴形成。这些微滴阵列成为在材料形成过程中指导材料组装的模板，并充当pH敏感平台，可进行高通量检测。此外，这种方法中分子模式的可调性有助于最大程度地降低基质辅助激光解吸/电离质谱法中的咖啡环效应和甜点问题。因此，CLL操作中的二维分子操作