Ortho- and meta-nitrobenzaldehydes are two important intermediates in the chemical industry. They are the main products of benzaldehyde nitration by mixed acid, which is a hazardous chemical process since reaction rates are very sensitive to variations of the operating conditions. In the present investigation, a previously developed kinetic model under homogeneous conditions is validated and extended for heterogeneous liquid-liquid systems. A comparison between performances of a lab-scale batch reactor and a commercial microreactor is also presented. The results show that microreactors with embedded static mixer can outperform scaled-up batch reactors, achieving the theoretical limit of conversion/yield attainable under kinetic control.

邻硝基和间硝基苯甲醛是化学工业中的两个重要中间体。它们是通过混合酸硝化苯甲醛的主要产品，这是一种危险的化学过程，因为反应速率对操作条件的变化非常敏感。在本研究中，先前开发的在均匀条件下的动力学模型已得到验证，并扩展到了非均质的液-液系统。还介绍了实验室规模的间歇反应器和商用微反应器的性能之间的比较。结果表明，带有嵌入式静态混合器的微反应器的性能优于按比例放大的间歇式反应器，达到了在动力学控制下可获得的理论转化率/产率的理论极限。