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PBr3-mediated unexpected reductive deoxygenation of α-aryl-pyridinemethanols: synthesis of arylmethylpyridines
Tetrahedron ( IF 2.1 ) Pub Date : 2016-02-26 13:52:45
Yosuke Nishigaya, Kentaro Umei, Daisuke Watanabe, Yasushi Kohno, Shigeki Seto

PBr3-mediated reductive deoxygenation of α-aryl-pyridinemethanols to provide arylmethylpyridines is described, the alcohol substrate scope is explored, free radical trap TEMPO (2,2,6,6-tetramethyl-1-piperidinyloxy) is introduced, and the hydrogen source of the methylene product is defined. The unexpected reaction enabled us to prepare previously inaccessible, novel EP1 antagonists.

中文翻译:

PBr3介导的α-芳基吡啶甲醇的意外还原性脱氧:芳基甲基吡啶的合成

描述了PBr 3介导的α-芳基吡啶甲醇的还原性脱氧以提供芳基甲基吡啶,探索了醇底物的范围,引入了自由基捕集剂TEMPO(2,2,6,6-四甲基-1-哌啶基氧基),以及氢定义了亚甲基产物的来源。出乎意料的反应使我们能够制备出以前无法获得的新型EP 1拮抗剂。
更新日期:2016-02-27
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