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On-Demand Dissolvable Self-Healing Hydrogel Based on Carboxymethyl Chitosan and Cellulose Nanocrystal for Deep Partial Thickness Burn Wound Healing
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2018-11-06 00:00:00 , DOI: 10.1021/acsami.8b14526 Weijuan Huang 1 , Yixiang Wang 1 , Zhiqiang Huang 2 , Xiaolan Wang 2 , Lingyun Chen 1 , Yu Zhang 2 , Lina Zhang 3
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2018-11-06 00:00:00 , DOI: 10.1021/acsami.8b14526 Weijuan Huang 1 , Yixiang Wang 1 , Zhiqiang Huang 2 , Xiaolan Wang 2 , Lingyun Chen 1 , Yu Zhang 2 , Lina Zhang 3
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Deep partial thickness burn wounds present big challenges due to the long healing time, large size and irregular shape, pain and reinjury at wound dressing changes, as well as scarring. The clinically effective therapy to alleviate pain at wound dressing changes, and the scar left on the skin after the healing of wound is still unavailable. To combat this, we develop a nanocomposite self-healing hydrogel that can be injected into irregular and deep burn wound beds and subsequently rapidly self-heal to reform into an integrated piece of hydrogel that thoroughly fills the wound area and protects the wound site from external environment, finally being painlessly removed by on-demand dissolving using amino acid solution at wound dressing changes, which accelerates deep partial thickness burn wound healing and prevents scarring. The hydrogel is made out of naturally occurring polymers, namely, water-soluble carboxymethyl chitosan (CMC) and rigid rod-like dialdehyde-modified cellulose nanocrystal (DACNC). They are cross-linked by dynamic Schiff-base linkages between amines from CMC and aldehydes from DACNC. The large aspect ratio and specific surface area of DACNC raise massive active junctions within the hydrogel, which can be readily broken and reformed, allowing hydrogel to rapidly self-heal. Moreover, DACNC serves as nanoreinforcing fillers to improve the hydrogel strength, which also restricts the “soft” CMC chains’ motion when soaked in aqueous system, endowing high fluid uptake capacity (350%) to hydrogel while maintaining integrity. Cytotoxicity assay and three-dimensional cell culture demonstrate excellent biocompatibility of the hydrogel and capacity as extracellular matrix to support cell growth. This work opens a novel pathway to fabricate on-demand dissolvable self-healing hydrogels to speed deep partial thickness burn wound healing and eliminate pain at wound dressing changes and prevent scar formation.
中文翻译：
基于羧甲基壳聚糖和纤维素纳米晶体的按需溶解自修复水凝胶，用于深部局部厚度烧伤创面愈合
由于愈合时间长，尺寸大且形状不规则，伤口敷料更换时的疼痛和再伤以及结疤，深厚的局部厚度烧伤创面带来了巨大挑战。减轻伤口敷料疼痛的临床有效疗法，伤口愈合后残留在皮肤上的疤痕仍然不可用。为了解决这个问题，我们开发了一种纳米复合自修复水凝胶，可以将其注射到不规则和深层烧伤创面中，然后迅速进行自修复，以重新制成完整的水凝胶片，从而彻底填充伤口区域并保护伤口部位免受外界伤害最终，在伤口敷料变化时，通过使用氨基酸溶液按需溶解可以最终无痛地去除伤口，从而加速深部局部烧伤创面的愈合并防止疤痕形成。水凝胶由天然存在的聚合物制成，即水溶性羧甲基壳聚糖（CMC）和刚性棒状二醛改性纤维素纳米晶体（DACNC）。它们通过CMC的胺与DACNC的醛之间的动态席夫碱键进行交联。DACNC的高长宽比和比表面积可在水凝胶中增加大量的活性连接，该连接易于断裂和重整，从而使水凝胶能够快速自愈。此外，DACNC用作纳米增强填料，以改善水凝胶强度，当浸泡在水性体系中时，它也限制了“软” CMC链的运动，赋予水凝胶以高的流体吸收能力（350％），同时保持完整性。细胞毒性测定和三维细胞培养证明水凝胶具有出色的生物相容性，并具有作为细胞外基质支持细胞生长的能力。这项工作为制造按需溶解的自修复水凝胶开辟了一条新途径，以加速深部局部厚度的烧伤伤口愈合，消除伤口敷料变化时的疼痛并防止疤痕形成。
更新日期：2018-11-06
中文翻译：
基于羧甲基壳聚糖和纤维素纳米晶体的按需溶解自修复水凝胶，用于深部局部厚度烧伤创面愈合
由于愈合时间长，尺寸大且形状不规则，伤口敷料更换时的疼痛和再伤以及结疤，深厚的局部厚度烧伤创面带来了巨大挑战。减轻伤口敷料疼痛的临床有效疗法，伤口愈合后残留在皮肤上的疤痕仍然不可用。为了解决这个问题，我们开发了一种纳米复合自修复水凝胶，可以将其注射到不规则和深层烧伤创面中，然后迅速进行自修复，以重新制成完整的水凝胶片，从而彻底填充伤口区域并保护伤口部位免受外界伤害最终，在伤口敷料变化时，通过使用氨基酸溶液按需溶解可以最终无痛地去除伤口，从而加速深部局部烧伤创面的愈合并防止疤痕形成。水凝胶由天然存在的聚合物制成，即水溶性羧甲基壳聚糖（CMC）和刚性棒状二醛改性纤维素纳米晶体（DACNC）。它们通过CMC的胺与DACNC的醛之间的动态席夫碱键进行交联。DACNC的高长宽比和比表面积可在水凝胶中增加大量的活性连接，该连接易于断裂和重整，从而使水凝胶能够快速自愈。此外，DACNC用作纳米增强填料，以改善水凝胶强度，当浸泡在水性体系中时，它也限制了“软” CMC链的运动，赋予水凝胶以高的流体吸收能力（350％），同时保持完整性。细胞毒性测定和三维细胞培养证明水凝胶具有出色的生物相容性，并具有作为细胞外基质支持细胞生长的能力。这项工作为制造按需溶解的自修复水凝胶开辟了一条新途径，以加速深部局部厚度的烧伤伤口愈合，消除伤口敷料变化时的疼痛并防止疤痕形成。
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