A collaborative program to discover new specialized metabolites from aquatic environments of Iceland led to the deconvolution of tetrahydroisoquinoline amide E/Z rotamers [(E/Z)-N-acetyl-MY336-a; 1] and conformers produced by a Streptomyces sp. All structures were elucidated by NMR and MS analysis, and interpretation of electronic circular dichroism (ECD) data. ECD and optical rotation (OR) simulations permitted the unequivocal assignment of the absolute configuration of compound 1 and provided an important example of delineating the spectroscopic contributions of equilibrating rotamers and boat/chair conformers of a common natural product scaffold.

一项合作计划从冰岛的水生环境中发现了新的专门代谢产物，导致四氢异喹啉酰胺E / Z旋转异构体[（E / Z）-N-乙酰基-MY336-a]解卷积。1 ]和由链霉菌属物种产生的构象体。通过NMR和MS分析以及对电子圆二色性（ECD）数据的解释，阐明了所有结构。ECD和旋光（OR）模拟允许化合物1的绝对构型的明确分配，并提供了一个重要的例子，说明了常见天然产物支架的旋转异构体和船/椅构象异构体在光谱学上的贡献。