Bone Cements: An Additive to PMMA Bone Cement Enables Postimplantation Drug Refilling, Broadens Range of Compatible Antibiotics, and Prolongs Antimicrobial Therapy (Adv. Healthcare Mater. 21/2018),Advanced Healthcare Materials

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Bone Cements: An Additive to PMMA Bone Cement Enables Postimplantation Drug Refilling, Broadens Range of Compatible Antibiotics, and Prolongs Antimicrobial Therapy (Adv. Healthcare Mater. 21/2018)
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2018-11-06 , DOI: 10.1002/adhm.201870080
Erika L. Cyphert ₁ , Greg D. Learn ₁ , Sara K. Hurley ₂ , Chao-yi Lu ₁ , Horst A. von Recum ₁

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Insoluble polymerized cyclodextrin microparticles entrap antibiotics in bone cement. The cement is then implanted into total joint replacements and is used to treat prolonged infections. In article 1800812, Horst A. von Recum and co‐workers show that this cyclodextrin‐based system has the ability to be refilled with drugs to extend therapy after implantation.

中文翻译：

骨水泥：PMMA骨水泥的添加剂可实现植入后药物补充，扩大兼容抗生素的范围并延长抗菌疗法（Adv。Healthcare Mater.21 / 2018）

不溶性聚合环糊精微粒将抗生素包埋在骨水泥中。然后将胶合剂植入全关节置换物中，并用于治疗长期感染。在文章1800812中，Horst A. von Recum及其同事表明，这种基于环糊精的系统具有在药物植入后重新填充药物以扩展治疗范围的能力。

更新日期：2018-11-06

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