通过一步式热键合技术制备的多层膜微反应器，具有很高的重现性及其应用<a href="#fn1" title="可用的电子补充信息（ESI）：具有各种通道尺寸的详细制造方法，压力测量以及液滴和化学药品生产的实验方法。参见DOI：10.1039 / c5lc01585e">†</a>,Lab on a Chip

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通过一步式热键合技术制备的多层膜微反应器，具有很高的重现性及其应用 †
Lab on a Chip ( IF 6.1 ) Pub Date : 2016-02-10 00:00:00 , DOI: 10.1039/c5lc01585e
Kyoung-Ik Min _{1,

2,

3,

4,

5} , Jin-Oh Kim _{1,

2,

3,

4,

5} , Heejin Kim _{6,

7,

8,

9} , Do Jin Im _{2,

5,

10,

11} , Dong-Pyo Kim _{1,

2,

3,

4,

5}

Affiliation

我们报告了具有各种功能的多层聚酰亚胺（PI）薄膜微反应器的广泛用途，包括压力耐受性，三维混合和多步膜乳化。这样的PI膜微反应器是通过简单的一步式热键合技术制造的，并且重复性高。在300°C下粘合1小时后，由于润湿性的差异，薄膜和柔性薄膜微器件分别使用PI粘合膜或含氟聚合物粘合剂可以承受的压力分别高达8.6 MPa和16.3 MPa。亲水性和疏水性微通道设备用于以高生成频率生成单分散的水包油（O / W）和油包水（W / O）小滴，以及聚合物微粒/纳米颗粒。¹毫秒的时间刻度。此外，还设计了一种用于有机-水双相界面反应的新型多层膜微反应器，方法是通过沿疏水通道流经多个网状结构，在界面和乳化相中嵌入膜层，从而在界面和乳化相中引起混沌混合。这种简单而经济的制造技术极大地促进了多层膜设备的批量生产，该设备可以用作化学和生物学中各种微流体应用的平台。

"点击查看英文标题和摘要"

Multilayered film microreactors fabricated by a one-step thermal bonding technique with high reproducibility and their applications†

We report the versatile uses of multilayered polyimide (PI) film microreactors with various functions including pressure tolerance, three-dimensional mixing and multistep membrane emulsification. Such PI film microreactors were fabricated by a simple one-step thermal bonding technique with high reproducibility. Upon bonding at 300 °C for 1 hour, the thin and flexible film microdevices could withstand pressure up to 8.6 MPa and 16.3 MPa with PI adhesive film or fluoropolymer adhesive, respectively, due to differences in wettability. The hydrophilic and hydrophobic microchannel devices were used to generate monodisperse oil-in-water (O/W) and water-in-oil (W/O) droplets, and polymer micro/nanoparticles at a high generation frequency. A monolithic and chemical resistant film microreactor with a three-dimensional serpentine microchannel was used for the selective reduction of ester to aldehyde by efficient mixing and quenching in a flash chemistry manner, within a several 10¹ millisecond time scale. Furthermore, a novel multilayered film microreactor for organic–aqueous biphasic interfacial reactions was devised by embedding a membrane layer to induce chaotic mixing in both the interface and emulsified phase by flowing through multiple numbers of meshed structures along the hydrophobic channel. This simple and economic fabrication technique significantly facilitates mass production of multilayered film devices that could be useful as a platform for various microfluidic applications in chemistry and biology.

更新日期：2016-02-10

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