FADD is part of most signalosome complexes including the necroptosome, FADDosome, innateosome and inflammasome. HumanFADDgene can be a potential driver in cancer through its amplification, which has been associated with both metastasis and poor overall survival for certain malignancies.

中文翻译：

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FADD在癌症和炎症之间的十字路口

FADD是大多数信号体复合物的一部分，包括坏死体，FADDosome，先天体和炎性体。HumanFADD基因通过其扩增可能成为癌症的潜在驱动因素，而这与某些恶性肿瘤的转移和较差的总体生存率有关。