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Biosynthesis of Plant Triterpenoid Saponins in Microbial Cell Factories
Journal of Agricultural and Food Chemistry ( IF 5.7 ) Pub Date : 2018-11-02 00:00:00 , DOI: 10.1021/acs.jafc.8b04657 Yu-jia Zhao 1 , Chun Li 1
Journal of Agricultural and Food Chemistry ( IF 5.7 ) Pub Date : 2018-11-02 00:00:00 , DOI: 10.1021/acs.jafc.8b04657 Yu-jia Zhao 1 , Chun Li 1
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Triterpenoid saponins are triterpenoid glycoside compounds which have been widely used in pharmaceutical, agricultural, and food industries. Traditionally, they are extracted from plants, which is time-consuming and environmentally unfriendly. Recently, de novo synthesis of triterpenoid saponins in microbial cell factories was realized, which provides a promising and green approach to alter the traditional supply way. However, the complex biosynthetic pathway and the poor suitability between the endogenous and heterogeneous pathways tremendously limit the yield of triterpenoid saponins. We introduce the biosynthetic pathways of triterpenoid saponins first, and we then summarize the microbial cell factories developed to produce these compounds. Further, we discuss the strategies applied to enhance the production. This paper systematically illustrates the biosynthesis of plant triterpenoid saponins in microbial cell factories.
中文翻译：
微生物细胞工厂中植物三萜皂苷的生物合成
三萜皂苷是三萜糖苷化合物，已广泛用于制药，农业和食品工业。传统上，它们是从植物中提取的，这既费时又对环境不利。最近，在微生物细胞工厂中实现了三萜皂苷的从头合成，这为改变传统的供应方式提供了一种有希望的绿色方法。但是，复杂的生物合成途径以及内源性和异质性途径之间的适用性差，极大地限制了三萜皂苷的产量。我们首先介绍三萜类皂苷的生物合成途径，然后我们总结开发产生这些化合物的微生物细胞工厂。此外，我们讨论了用于提高产量的策略。
更新日期：2018-11-02
中文翻译：
微生物细胞工厂中植物三萜皂苷的生物合成
三萜皂苷是三萜糖苷化合物，已广泛用于制药，农业和食品工业。传统上，它们是从植物中提取的，这既费时又对环境不利。最近，在微生物细胞工厂中实现了三萜皂苷的从头合成，这为改变传统的供应方式提供了一种有希望的绿色方法。但是，复杂的生物合成途径以及内源性和异质性途径之间的适用性差，极大地限制了三萜皂苷的产量。我们首先介绍三萜类皂苷的生物合成途径，然后我们总结开发产生这些化合物的微生物细胞工厂。此外，我们讨论了用于提高产量的策略。
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