Methylated Polycyclic Polyprenylated Acylphloroglucinol Derivatives from Hypericum ascyron.,Journal of Natural Products

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Methylated Polycyclic Polyprenylated Acylphloroglucinol Derivatives from Hypericum ascyron.
Journal of Natural Products ( IF 3.3 ) Pub Date : 2018-10-31 , DOI: 10.1021/acs.jnatprod.8b00176
Jia-Wen Hu ₁ , Meng-Jiao Shi ₁ , Jia-Jia Wang ₁ , Li Li ₁ , Jian-Dong Jiang ₁ , Teng-Fei Ji ₁

Affiliation

Hyperascyrins A-H (1-11) and four known compounds (12-15) were acquired from the air-dried aerial parts of Hypericum ascyron and were all identified as methylated polycyclic polyprenylated acylphloroglucinol derivatives. Their structures were established by NMR spectroscopy, experimental and calculated electronic circular dichroism (ECD) data, and comparison with established compounds. Compounds 8 and 9 showed protection against paracetamol-induced HepG2 cell damage at 10 μM. The neuroprotective activities of all compounds (10 μM) were evaluated, and compounds 1 and 8 exhibited mild neuroprotection against glutamate-induced toxicity in SK-N-SH cells.

中文翻译：

贯叶连翘的甲基化多环多戊烯基化酰基间苯三酚衍生物。

金丝桃属植物AH（1-11）和四种已知化合物（12-15）购自金丝桃属植物Ascyron的风干地上部分，均被鉴定为甲基化的多环多烯丙基化酰基间苯三酚衍生物。它们的结构通过NMR光谱，实验和计算的电子圆二色性（ECD）数据建立，并与确定的化合物进行比较。化合物8和9在10μM时显示出对乙酰氨基酚诱导的HepG2细胞损伤的保护作用。评估了所有化合物（10μM）的神经保护活性，化合物1和8对谷氨酸诱导的SK-N-SH细胞毒性具有轻度的神经保护作用。

更新日期：2018-10-31

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