Two new cyclic heptapeptides, carteritins A and B (1 and 2), were isolated from the marine sponge Stylissa carteri along with three known cyclic heptapeptides, phakellistatin 13 (3) and hymenamides C and D (4 and 5). Their structures were elucidated based on data obtained using 2D NMR, HRESIMS, and ESIMS/MS, in addition to Marfey’s analysis. Carteritin A (1) showed cytotoxicities against HeLa, HCT116, and RAW264 cells with IC₅₀ values of 0.70–1.5μM.

中文翻译：

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软骨素A和B，来自海洋海绵针状针孢菌的环状七肽

从海洋海绵针St中分离出两个新的环状七肽，软骨素A和B（1和2），以及三个已知的环状七肽，phakellistatin 13（3）和处女膜酰胺C和D（4和5）。除了使用Marfey的分析之外，还基于使用2D NMR，HRESIMS和ESIMS / MS获得的数据阐明了它们的结构。Carteritin A（1）对HeLa，HCT116和RAW264细胞表现出细胞毒性，IC ₅₀值为0.70–1.5μM。