In the previous study, Glycyrrhiza uralensis Fisch extract (GUE) inhibited Aβ secretion by inhibiting β‐site APP‐cleaving enzyme 1 (BACE1) transcription, and the active compounds semilicoisoflavone B (SB) and licoflavonol (LF) inhibited Aβ secretion. SB corresponds to the same mechanism as GUE, but LF has a different mechanism. In this study, the mechanism underlying inhibition of Aβ by LF is investigated.

中文翻译：

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柠檬黄酮醇通过增加BACE1磷酸化以促进BACE1降解来减少Aβ分泌

在先前的研究中，甘草Fisch提取物（GUE）通过抑制β-位APP裂解酶1（BACE1）的转录来抑制Aβ的分泌，而活性化合物Semilicoisoflavone B（SB）和脂黄酮（LF）可以抑制Aβ的分泌。SB与GUE对应相同的机制，但是LF具有不同的机制。在这项研究中，研究了LF抑制Aβ的潜在机制。