Tissue adhesion is one of the most common complications after surgery (especially after abdominal surgery), causing notable influences after the damaged tissue has healed. A physical barrier placed between the wound site and the adjacent tissues is a convenient and highly effective technique to minimize or prevent abdominal adhesions. In this work, the N, O-carboxymethyl chitosan/oxidized regenerated cellulose (N, O-CS/ORC) composite gauze was prepared. The N, O-CS/ORC composite gauze is degradable; in addition, the gauze exhibits excellent antimicrobial functionality against S. aureus and E. coli bacteria. Moreover, the notable hemostatic efficacy of the N, O-CS/ORC composite gauze was confirmed in rabbit livers/ears as models. The results showed that the N, O-CS/ORC composite gauze is nontoxic toward normal cells and can restrain the adhesion of fibroblast cells, thereby indicating its potential use in preventing tissue adhesion. In addition, the rat models for abdominal defect-cecum abrasion were used to evaluate the efficacy of N, O-CS/ORC composite gauze in preventing tissue adhesions after surgery. The results indicated that the N, O-CS/ORC composite gauze can significantly prevent postsurgical peritoneal adhesions. Finally, the potential anti-adhesion mechanism of the N, O-CS/ORC composite gauze, which may attribute to the combination of barrier function and instinct activity of N, O-CS and ORC, was investigated.

组织粘连是手术后（尤其是腹部手术后）最常见的并发症之一，在受损组织愈合后会产生显着影响。放置在伤口部位和相邻组织之间的物理屏障是一种方便有效的技术，可最大程度地减少或防止腹部粘连。在这项工作中，制备了N，O-羧甲基壳聚糖/氧化再生纤维素（N，O-CS / ORC）复合纱布。的N，O-CS / ORC复合纱是可降解的; 此外，纱布对金黄色葡萄球菌和大肠杆菌具有极好的抗菌功能。此外，N，O-CS / ORC具有明显的止血功效在兔肝/耳中证实了复合纱布为模型。结果表明，N，O-CS / ORC复合纱布对正常细胞无毒，可以抑制成纤维细胞的粘附，从而表明其在预防组织粘附方面的潜在用途。此外，使用大鼠腹部-盲肠盲肠擦伤模型来评估N，O-CS / ORC复合纱布在预防术后组织粘连方面的功效。结果表明，N，O-CS / ORC复合纱布可显着预防术后腹膜粘连。最后，N，O-CS / ORC的潜在抗粘连机制 对复合纱布进行了研究，它可能归因于N，O-CS和ORC的屏障功能和本能活性的结合。