当前位置：
X-MOL 学术
›
Chem. Asian J.
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Cover Feature: A Biotinylated and Endoplasmic Reticulum‐Targeted Glutathione‐Responsive Zinc(II) Phthalocyanine for Targeted Photodynamic Therapy (Chem. Asian J. 22/2018)
Chemistry - An Asian Journal ( IF 3.5 ) Pub Date : 2018-10-26 , DOI: 10.1002/asia.201801304 Ligang Yu 1 , Qiong Wang 1 , Ka-Wing Yeung 2 , Wing-Ping Fong 2 , Pui-Chi Lo 1
Chemistry - An Asian Journal ( IF 3.5 ) Pub Date : 2018-10-26 , DOI: 10.1002/asia.201801304 Ligang Yu 1 , Qiong Wang 1 , Ka-Wing Yeung 2 , Wing-Ping Fong 2 , Pui-Chi Lo 1
Affiliation
|
A biotinylated and endoplasmic reticulum (ER)‐targeted glutathione (GSH)‐responsive zinc(II) phthalocyanine was developed for targeted photodynamic therapy. With a quenching moiety, the fluorescence emission and singlet oxygen generation of the phthalocyanine are quenched in its intact state. Upon exposure to a high concentration of GSH, its photosensitizing properties could be restored in phosphate‐buffered saline and inside tumor cells. In addition, the conjugate exhibited higher cellular uptake in biotin receptor‐positive cancer cells and induced potent cytotoxicity upon irradiation. It could cause ER stress after light irradiation, as reflected by the increased level of intracellular Ca2+, GRP78, and C/EBP homologous protein (CHOP) protein markers. More information can be found in the Full Paper by Wing‐Ping Fong, Pui‐Chi Lo et al. on page 3509 in Issue 22, 2018 (DOI: 10.1002/asia.201800852).
中文翻译：
封面功能：一种靶向生物素化和内质网的谷胱甘肽反应性酞菁锌（II），用于靶向光动力疗法（Chem.Asian J.22 / 2018）
开发了一种针对生物素化和内质网（ER）的谷胱甘肽（GSH）响应性锌（II）酞菁锌，用于靶向光动力疗法。通过淬灭部分，酞菁的荧光发射和单线态氧生成在其完整状态下被淬灭。暴露于高浓度的GSH后，其光敏特性可以在磷酸盐缓冲液和肿瘤细胞内部恢复。此外，结合物在生物素受体阳性癌细胞中显示出更高的细胞摄取，并在辐射后诱导出强力的细胞毒性。细胞内Ca 2+含量升高反映了光照射后可能引起内质网应激。，GRP78和C / EBP同源蛋白（CHOP）蛋白标记。有关更多信息，请参见Fing-Chi Fong的Wing-Ping Fong等人的论文。就在第22期，2018页3509（：10.1002 / asia.201800852 DOI）。
更新日期：2018-10-26
中文翻译：
封面功能：一种靶向生物素化和内质网的谷胱甘肽反应性酞菁锌（II），用于靶向光动力疗法（Chem.Asian J.22 / 2018）
开发了一种针对生物素化和内质网（ER）的谷胱甘肽（GSH）响应性锌（II）酞菁锌，用于靶向光动力疗法。通过淬灭部分，酞菁的荧光发射和单线态氧生成在其完整状态下被淬灭。暴露于高浓度的GSH后，其光敏特性可以在磷酸盐缓冲液和肿瘤细胞内部恢复。此外，结合物在生物素受体阳性癌细胞中显示出更高的细胞摄取，并在辐射后诱导出强力的细胞毒性。细胞内Ca 2+含量升高反映了光照射后可能引起内质网应激。，GRP78和C / EBP同源蛋白（CHOP）蛋白标记。有关更多信息，请参见Fing-Chi Fong的Wing-Ping Fong等人的论文。就在第22期，2018页3509（：10.1002 / asia.201800852 DOI）。
京公网安备 11010802027423号