Nature Reviews Genetics ( IF 39.1 ) Pub Date : 2018-10-24 , DOI: 10.1038/s41576-018-0063-5 Abigail Buchwalter 1, 2, 3 , Jeanae M Kaneshiro 1 , Martin W Hetzer 1
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The genome is packaged and organized nonrandomly within the 3D space of the nucleus to promote efficient gene expression and to faithfully maintain silencing of heterochromatin. The genome is enclosed within the nucleus by the nuclear envelope membrane, which contains a set of proteins that actively participate in chromatin organization and gene regulation. Technological advances are providing views of genome organization at unprecedented resolution and are beginning to reveal the ways that cells co-opt the structures of the nuclear periphery for nuclear organization and gene regulation. These genome regulatory roles of proteins of the nuclear periphery have important influences on development, disease and ageing.
中文翻译：
场外辅导：基因组调控中的核外围
基因组在细胞核的 3D 空间内非随机包装和组织，以促进有效的基因表达并忠实地保持异染色质的沉默。基因组被核膜包裹在细胞核内，核膜包含一组积极参与染色质组织和基因调控的蛋白质。技术进步以前所未有的分辨率提供了基因组组织的观点，并开始揭示细胞利用核外围结构进行核组织和基因调控的方式。核外围蛋白质的这些基因组调控作用对发育、疾病和衰老具有重要影响。
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