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Porphyrin–ferrocene conjugates for photodynamic and chemodynamic therapy
Organic & Biomolecular Chemistry ( IF 2.9 ) Pub Date : 2018-10-25 , DOI: 10.1039/c8ob02391c
Zhitao Lei 1, 2, 3, 4, 5 , Xiaoyu Zhang 1, 2, 3, 4 , Xiaohua Zheng 4, 5, 6, 7, 8 , Shi Liu 4, 5, 6, 7, 8 , Zhigang Xie 4, 5, 6, 7, 8
Organic & Biomolecular Chemistry ( IF 2.9 ) Pub Date : 2018-10-25 , DOI: 10.1039/c8ob02391c
Zhitao Lei 1, 2, 3, 4, 5 , Xiaoyu Zhang 1, 2, 3, 4 , Xiaohua Zheng 4, 5, 6, 7, 8 , Shi Liu 4, 5, 6, 7, 8 , Zhigang Xie 4, 5, 6, 7, 8
Affiliation
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Chemodynamic therapy can convert endogenous hydrogen peroxide (H2O2) at tumor localization into the toxic hydroxyl radical (˙OH) destroying tumor cells. Photodynamic therapy as a noninvasive method utilizes photosensitizers (PSs) to convert O2 into cytotoxic reactive oxygen species (e.g., 1O2) upon laser irradiation, which is dependent on the content of oxygen. The combination of the two therapeutic strategies on a single platform can enhance the anticancer effect. Herein, we report a porphyrin–ferrocene theranostic agent for combined photodynamic and chemodynamic therapy. Compared to monotherapy, the as-prepared porphyrin–ferrocene conjugates exhibit superior efficiency and potency in killing cancer cells at low drug doses. This study suggests the rational design of molecular structures as multifunctional therapeutics for potential clinic application.
中文翻译:
卟啉-二茂铁结合物用于光动力和化学动力疗法
化学动力疗法可将肿瘤定位处的内源性过氧化氢(H 2 O 2)转化为破坏肿瘤细胞的毒性羟基(˙OH)。光动力疗法作为一种非侵入性方法利用光敏剂(PSS)至O转换2为细胞毒性活性氧类(例如,1 Ò 2),取决于氧气含量。两种治疗策略在单个平台上的组合可以增强抗癌作用。在这里,我们报告了卟啉-二茂铁治疗剂,用于光动力和化学动力疗法的联合治疗。与单一疗法相比,制备的卟啉-二茂铁结合物在低药物剂量下具有杀死癌细胞的优异效率和效力。这项研究提出了合理设计分子结构作为多功能治疗剂的潜在临床应用。
更新日期:2018-11-15
中文翻译:
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卟啉-二茂铁结合物用于光动力和化学动力疗法
化学动力疗法可将肿瘤定位处的内源性过氧化氢(H 2 O 2)转化为破坏肿瘤细胞的毒性羟基(˙OH)。光动力疗法作为一种非侵入性方法利用光敏剂(PSS)至O转换2为细胞毒性活性氧类(例如,1 Ò 2),取决于氧气含量。两种治疗策略在单个平台上的组合可以增强抗癌作用。在这里,我们报告了卟啉-二茂铁治疗剂,用于光动力和化学动力疗法的联合治疗。与单一疗法相比,制备的卟啉-二茂铁结合物在低药物剂量下具有杀死癌细胞的优异效率和效力。这项研究提出了合理设计分子结构作为多功能治疗剂的潜在临床应用。