The introduction of fluorine atoms into an organic molecule has become an important research field since fluorinated compounds play crucial roles in life science and materials chemistry. Among various fluorinated moieties, the difluoroethyl group (CF₂CH₃) mimics the steric and electronic features of a methoxy group, and this modification can often bring about many beneficial effects to the target molecules. This feature article summarizes the presently known methods for the synthesis of (1,1-difluoroethyl)arenes, including nucleophilic, electrophilic, and free radical fluorination or 1,1-difluoroethylation reactions.

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（1,1-二氟乙基）芳烃合成的最新进展

由于氟化物在生命科学和材料化学中起着至关重要的作用，因此将氟原子引入有机分子已成为一个重要的研究领域。在各种氟化部分中，二氟乙基（CF ₂ CH ₃）模仿甲氧基的空间和电子特征，并且这种修饰通常可以对靶分子带来许多有益的作用。该专题文章概述了目前合成（1,1-二氟乙基）芳烃的已知方法，包括亲核，亲电和自由基氟化或1,1-二氟乙基化反应。