裸露和经空间稳定的PLGA纳米颗粒，用于稳定Pickering乳液,Langmuir

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裸露和经空间稳定的PLGA纳米颗粒，用于稳定Pickering乳液
Langmuir ( IF 3.7 ) Pub Date : 2018-10-23 00:00:00 , DOI: 10.1021/acs.langmuir.8b02558
Claire Albert ₁ , Nicolas Huang ₁ , Nicolas Tsapis ₁ , Sandrine Geiger _{1,

2} , Véronique Rosilio ₁ , Ghozlene Mekhloufi ₁ , David Chapron ₁ , Baptiste Robin ₁ , Mohamed Beladjine ₁ , Valérie Nicolas ₃ , Elias Fattal ₁ , Florence Agnely ₁

Affiliation

Pickering乳液，使用生物可降解的和生物相容的聚（乳酸-配制共（乙醇酸）（PLGA）纳米粒子（NPs），无需使用表面活性剂或PLGA以外的任何其他聚合物。选择药物和化妆品油（Miglyol）作为油相，比例为10％w / w。然后将这些乳液与使用相同油但配制成众所周知的PLGA-聚乙烯醇（PVA）NP，即以PVA作为NP稳定剂的乳液进行比较。令人惊讶的是，根据所用NP的类型，乳液在宏观，微观和界面尺度上都表现出截然不同的结构。实际上，当使用PLGA NP而不是PLGA-PVA NP时，乳剂层会明显增厚。这归因于使用单一乳化步骤形成的多个水包油包水（W / O / W）和简单水包油（O / W）小滴的形成和共存，而简单O用PLGA-PVA NP获得/ W乳液。后者的NPs比裸露的PLGA NPs更亲水，因为它们表面存在PVA。此外，PLGA NPs仅略微降低了油/水界面张力，而PLGA-PVA NPs的降低更为明显。PLGA-PVA NP表面的PVA链可能会部分从NP解吸并吸附在界面上，从而导致界面张力降低。最后，不考虑其组成，NPs可能会由于其在界面上的流动性而吸附在油/水界面上，而不会影响其流变性。这项工作对Pickering乳液的配方具有直接的影响，并强调了NP表面的物理化学性质对稳定这些系统的至关重要的影响。

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Bare and Sterically Stabilized PLGA Nanoparticles for the Stabilization of Pickering Emulsions

Pickering emulsions were formulated using biodegradable and biocompatible poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) prepared without surfactants or any other polymer than PLGA. A pharmaceutical and cosmetic oil (Miglyol) was chosen as the oil phase at a ratio of 10% w/w. These emulsions were then compared with emulsions using the same oil but formulated with well-described PLGA-poly(vinyl alcohol) (PVA) NPs, i.e., with PVA as NP stabilizers. Strikingly, the emulsions demonstrated very different structures at macroscopic, microscopic, and interfacial scales, depending on the type of NPs used. Indeed, the emulsion layer was significantly thicker when using PLGA NPs rather than PLGA-PVA NPs. This was attributed to the formation and coexistence of multiple water-in-oil-in-water (W/O/W) and simple oil-in-water (O/W) droplets, using a single step of emulsification, whereas simple O/W emulsions were obtained with PLGA-PVA NPs. The latter NPs were more hydrophilic than bare PLGA NPs because of the presence of PVA at their surface. Moreover, PLGA NPs only slightly lowered the oil/water interfacial tension whereas the decrease was more pronounced with PLGA-PVA NPs. The PVA chains at the PLGA-PVA NP surface could probably partially desorb from the NPs and adsorb at the interface, inducing the interfacial tension decrease. Finally, independent of their composition, NPs were adsorbed at the oil/water interface without influencing its rheological behavior, possibly due to their mobility at their interface. This work has direct implications in the formulation of Pickering emulsions and stresses the paramount influence of the physicochemical nature of the NP surface into the stabilization of these systems.

更新日期：2018-10-23

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