It is imperative to develop organic photosensitizers for both photothermal and photodynamic therapy under same irradiation. Herein, we design a simple TEG-borondipyrromethene (TBDP) with very low fluorescence quantum yield (Φ_f = 2%), possessing excellent photothermal and photodynamic efficacy. The introduction of TEG can improve the water solubility of borondipyrromethene (BODIPY) and facilitate the assembly of TBDP to form stable nanoparticles. The formed TBDP nanoparticles possess excellent photothermal and photodynamic efficacy. When the nanoparticle was internalized by cells and irradiated by 635 nm red light, it would generate both singlet oxygen and heat to kill the cells, exhibiting excellent phototoxicity and photostability. The results of in vivo anti-tumor experiment further confirm its outstanding phototoxicity. This work provides a new platform in biomedical field and cancer treatment.

必须开发在相同照射下用于光热疗法和光动力疗法的有机光敏剂。在此，我们设计了一个简单的TEG-硼二（TBDP）具有非常低的荧光量子产率（Φ _˚F  = 2％），其具有优良的光热和光动力学效力。TEG的引入可以提高硼二吡咯亚甲基（BODIPY）的水溶性，并促进TBDP的组装以形成稳定的纳米颗粒。所形成的TBDP纳米颗粒具有优异的光热和光动力功效。当纳米粒子被细胞内化并被635 nm红光照射时，它将同时产生单线态氧和热量以杀死细胞，表现出出色的光毒性和光稳定性。体内结果抗肿瘤实验进一步证实了其出色的光毒性。这项工作为生物医学领域和癌症治疗提供了一个新的平台。