<i>叔</i>丁基过氧化氢存在下的一锅磁性氧化铁碳纳米点复合催化环氧化水串联合成喹唑啉酮,ACS Omega

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叔丁基过氧化氢存在下的一锅磁性氧化铁碳纳米点复合催化环氧化水串联合成喹唑啉酮
ACS Omega ( IF 3.7 ) Pub Date : 2018-10-19 00:00:00 , DOI: 10.1021/acsomega.8b01794
Biju Majumdar ₁ , Daisy Sarma ₁ , Siddarth Jain ₁ , Tridib K. Sarma ₁

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在水性介质中使用生物相容性催化剂开发生物重要分子的合成方案，是绿色和可持续化学的关键。在此，已证明可磁回收的氧化铁-碳点纳米复合材料是在以醇为原料的水性介质中环氧化串联合成喹唑啉酮的有效催化剂。荧光碳点是纳米碳家族中最新的进入剂，被用作氧化铁纳米颗粒的稳定剂，并且通过透射电子显微镜观察，连续的碳点层装饰着氧化铁纳米颗粒的表面。荧光研究表明，有效的电子从碳点转移到了氧化铁纳米颗粒，由于碳点导致发射完全淬灭，一旦与氧化铁纳米粒子结合。该纳米催化剂具有高活性，在甲醇存在下对喹唑啉酮类化合物的合成具有显着的可重用性。水性介质中的叔丁基过氧化氢（TBHP）。对照实验揭示了碳点在增强氧化铁催化活性方面的协同作用，因为它们由于其过氧化物酶活性而可能影响TBHP分解为自由基。已知与基于溶液的自由基相比，稳定在纳米颗粒表面上的这些自由基具有延长的寿命。这些表面稳定的自由基然后可以催化串联反应，从而以高收率形成喹唑啉酮衍生物。

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One-Pot Magnetic Iron Oxide–Carbon Nanodot Composite-Catalyzed Cyclooxidative Aqueous Tandem Synthesis of Quinazolinones in the Presence of tert-Butyl Hydroperoxide

The development of synthetic protocols for biologically important molecules using biocompatible catalysts in aqueous medium holds the key in green and sustainable chemistry. Herein, a magnetically recoverable iron oxide–carbon dot nanocomposite has been demonstrated as an effective catalyst for cyclooxidative tandem synthesis of quinazolinones in aqueous medium using alcohols as starting materials. Fluorescent carbon dots, the newest entrant in the nanocarbon family, were used as the stabilizing agent for the iron oxide nanoparticles, and a continuous layer of carbon dots decorates the iron oxide nanoparticle surface as observed by transmission electron microscopy. The fluorescence studies demonstrated the effective electron transfer from carbon dots to the iron oxide nanoparticles resulting in complete quenching of emission owing to carbon dots, once it binds with iron oxide nanoparticles. The nanocatalyst showed high activity with significant reusability for the syntheses of quinazolinones in the presence of tert-butyl hydroperoxide (TBHP) in an aqueous medium. Controlled experiments revealed the synergistic effect of carbon dots in enhancing the catalytic activity of iron oxide, as they might influence the decomposition of TBHP into radicals owing to their peroxidase activity. These radicals stabilized over the nanoparticle surface are known to have increased lifetime compared to solution-based radicals. These surface-stabilized radicals then could catalyze the tandem reaction resulting in the formation of the quinazolinone derivatives in high yields.

更新日期：2018-10-19

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