Efficient Synthesis of Photoreactive 2-Propoxyaniline Derivatives as Artificial Sweeteners,Synlett

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Efficient Synthesis of Photoreactive 2-Propoxyaniline Derivatives as Artificial Sweeteners
Synlett ( IF 1.7 ) Pub Date : 2015-12-14 , DOI: 10.1055/s-0035-1561275
Yuta Murai ₁ , Makoto Hashimoto ₂ , Takuma Yoshida ₂ , Lei Wang ₂ , Katsuyoshi Masuda ₃ , Yasuyuki Hashidoko ₂ , Kenji Monde ₁ , Yasumaru Hatanaka ₄

Affiliation

5-Nitro-2-propoxyaniline is one of the strongest artificial sweeteners. However, little is known about the detailed relationship of the structure and biological activity between 5-nitro-2-propoxyaniline and its sweet receptor. Photoaffinity labeling is a useful method for revealing interactions of a small bioactive compound with molecules. Therefore, we synthesized photoreactive 2-propoxyaniline derivatives as useful tools for revealing the interactions by photoaffinity labeling.

中文翻译：

作为人工甜味剂的光反应性 2-丙氧基苯胺衍生物的有效合成

5-Nitro-2-丙氧基苯胺是最强的人造甜味剂之一。然而，关于5-硝基-2-丙氧基苯胺与其甜味受体之间的结构和生物活性的详细关系知之甚少。光亲和标记是揭示小生物活性化合物与分子相互作用的有用方法。因此，我们合成了光反应性 2-丙氧基苯胺衍生物作为通过光亲和标记揭示相互作用的有用工具。

更新日期：2015-12-14

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