The American Society of Human Genetics (ASHG) is alarmed to see a societal resurgence of groups rejecting the value of genetic diversity and using discredited or distorted genetic concepts to bolster bogus claims of white supremacy. ASHG denounces this misuse of genetics to feed racist ideologies. In public dialog, our research community should be clear about genetic knowledge related to ancestry and genomic diversity. To that end, ASHG affirms the following:•Genetics demonstrates that humans cannot be divided into biologically distinct subcategories. Although there are clear observable correlations between variation in the human genome and how individuals identify by race, the study of human genetics challenges the traditional concept of different races of humans as biologically separate and distinct. This is validated by many decades of research, including recent examples.1,2Jorde L.B.Wooding S.P.Genetic variation, classification and ‘race’.Nat. Genet.2004;36:S28-S33CrossrefPubMedGoogle Scholar,3Keita S.O.Y.Kittles R.A.Royal C.D.M.Bonney G.E.Furbert-Harris P.Dunston G.M.Rotimi C.N.Conceptualizing human variation.Nat. Genet.2004;36:S17-S20CrossrefPubMedScopus (0)Google Scholar,4Rotimi C.N.Are medical and nonmedical uses of large-scale genomic markers conflating genetics and ‘race’?.Nat. Genet.2004;36:S43-S47CrossrefPubMedScopus (0)Google Scholar,5Yudell M.Roberts D.DeSalle R.Tishkoff S.Science and society. Taking race out of human genetics.Science.2016;351:564-565CrossrefPubMedGoogle Scholar,6Baker J.L.Rotimi C.N.Shriner D.Human ancestry correlates with language and reveals that race is not an objective genomic classifier.Sci. Rep.2017;7:1572CrossrefPubMedScopus (7)Google Scholar•Most human genetic variation is distributed as a gradient, so distinct boundaries between population groups cannot be accurately assigned. There is considerable genetic overlap among members of different populations. Such patterns of genome variation are explained by patterns of migration and mixing of different populations throughout human history.7Hellenthal G.Busby G.B.J.Band G.Wilson J.F.Capelli C.Falush D.Myers S.A genetic atlas of human admixture history.Science.2014;343:747-751CrossrefPubMedScopus (223)Google ScholarIn this way, genetics exposes the concept of “racial purity” as scientifically meaningless.•It follows that there can be no genetics-based support for claiming one group as superior to another. Although a person’s genetics influences their phenotypic characteristics, and self-identified race might be influenced by physical appearance, race itself is a social construct. Any attempt to use genetics to rank populations demonstrates a fundamental misunderstanding of genetics.•The past decade has seen the emergence of strategies for assessing an individual’s genetic ancestry. Such analyses8Royal C.D.Novembre J.Fullerton S.M.Goldstein D.B.Long J.C.Bamshad M.J.Clark A.G.Inferring genetic ancestry: Opportunities, challenges, and implications.Am. J. Hum. Genet.2010;86:661-673AbstractFull TextFull Text PDFPubMedScopus (0)Google Scholarare providing increasingly accurate ways of helping to define individuals’ ancestral origins and enabling new ways to explore and discuss ancestries that move us beyond blunt definitions of self-identified race.

中文翻译：

---

ASHG谴责将遗传与种族至上联系起来的尝试。

美国人类遗传学会（ASHG）震惊地看到，一群拒绝接受遗传多样性价值并利用信誉不佳或歪曲的遗传概念来支持白人至上的虚假主张的群体重新出现。ASHG谴责这种滥用基因来滋养种族主义意识形态的行为。在公开对话中，我们的研究界应清楚了解与祖先和基因组多样性有关的遗传知识。为此，ASHG确认以下几点：•遗传学证明不能将人类分为生物学上不同的亚类。尽管人类基因组的变异与个体如何通过种族进行识别之间存在明显的相关关系，但人类遗传学的研究挑战了人类不同种族的传统观念，即它们在生物学上是分离的和截然不同的。数十年来的研究证实了这一点，包括最近的例子。1,2，Jorde LBWooding SP遗传变异，分类和“种族”。Genet.2004; 36：S28-S33CrossrefPubMedGoogle Scholar，3Keita SOYKittles RA皇家CDMBonney GEFurbert-Harris P.Dunston GMRotimi CNConceptualizing人类变异。Genet.2004; 36：S17-S20CrossrefPubMedScopus（0）Google学术搜索，4Rotimi CNA大规模整合了遗传学和“种族”的基因组标记在医学和非医学领域的应用。Genet.2004; 36：S43-S47CrossrefPubMedScopus（0）Google Scholar，5Yudell M.Roberts D.DeSalle R.Tishkoff S.Science and society。从人类遗传学中消除种族。科学（Science）.2016; 351：564-565CrossrefPubMedGoogle Scholar，6 Rep.2017; 7：1572CrossrefPubMedScopus（7）Google Scholar•大多数人类遗传变异都以梯度分布，因此无法准确分配人群之间的明显界限。不同群体成员之间存在相当大的遗传重叠。人类历史上不同种群的迁移和混合模式解释了这种基因组变异模式.7 Hellenthal G.Busby GBJBand G.Wilson JFCapelli C.Falush D.Myers SA人类混合物历史遗传图谱。科学.2014; 343：747 -751CrossrefPubMedScopus（223）Google学术搜索通过这种方式，遗传学揭示了“种族纯度”的概念在科学上毫无意义。尽管一个人的遗传学会影响他们的表型特征，自我认同的种族可能会受到外表的影响，种族本身就是一种社会建构。任何使用遗传学对种群进行排名的尝试都表明了对遗传学的根本误解。•过去十年来，出现了评估个人遗传学谱系的策略。皇家遗传学家J.Fullerton SMGoldstein DBLong JCBamshad MJClark AG推断遗传祖先：机遇，挑战和启示。J.哼 Genet.2010; 86：661-673AbstractFull TextFull Text PDFPubMedScopus（0）Google学术搜索提供了越来越准确的方法来帮助定义个人的祖先起源，并提供探索和讨论祖先的新方法，这些方法使我们超越了对自我识别种族的直白定义。种族本身是一种社会建构。任何使用遗传学对种群进行排名的尝试都表明了对遗传学的根本误解。•过去十年来，出现了评估个人遗传学谱系的策略。皇家遗传学家J.Fullerton SMGoldstein DBLong JCBamshad MJClark AG推断遗传祖先：机遇，挑战和启示。J.哼 Genet.2010; 86：661-673AbstractFull TextFull Text PDFPubMedScopus（0）Google学术搜索提供了越来越准确的方法来帮助定义个人的祖先起源，并提供探索和讨论祖先的新方法，这些方法使我们超越了对自我识别种族的直白定义。种族本身是一种社会建构。任何使用遗传学对种群进行排名的尝试都表明了对遗传学的根本误解。•过去十年来，出现了评估个人遗传学谱系的策略。皇家遗传学家J.Fullerton SMGoldstein DBLong JCBamshad MJClark AG推断遗传祖先：机遇，挑战和启示。J.哼 Genet.2010; 86：661-673AbstractFull TextFull Text PDFPubMedScopus（0）Google学术搜索提供了越来越准确的方法来帮助定义个人的祖先起源，并提供探索和讨论祖先的新方法，这些方法使我们超越了对自我识别种族的直白定义。•在过去的十年中，出现了评估个人遗传谱系的策略。皇家遗传学家J.Fullerton SMGoldstein DBLong JCBamshad MJClark AG推断遗传祖先：机遇，挑战和启示。J.哼 Genet.2010; 86：661-673AbstractFull TextFull Text PDFPubMedScopus（0）Google学术搜索提供了越来越准确的方法来帮助定义个人的祖先起源，并提供探索和讨论祖先的新方法，这些方法使我们超越了对自我识别种族的直白定义。•在过去的十年中，出现了评估个人遗传谱系的策略。皇家遗传学家J.Fullerton SMGoldstein DBLong JCBamshad MJClark AG推断遗传祖先：机遇，挑战和启示。J.哼 Genet.2010; 86：661-673AbstractFull TextFull Text PDFPubMedScopus（0）Google学术搜索提供了越来越准确的方法来帮助定义个人的祖传起源，并提供探索和讨论祖先的新方法，这些方法使我们超越了对自我识别种族的直白定义。