Glaulactams A-C (1-3), which possess a novel skeleton, as well as the known compound daphmanidin B (4), were isolated from the leaves of Daphniphyllum glaucescens and separated using ion-exchange chromatography aided by NMR fingerprinting. Their structures, including their absolute configurations, were elucidated by spectroscopic analyses and time-dependent density-functional-theory-calculated electronic circular dichroism spectra; the data were subsequently analyzed to gain insight into the respective biogenetic relationships between the isolates, which exhibited anti-H1N1 and immunosuppressive activities.

中文翻译：

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Glaulaactams AC，来自 Daphniphyllum glaucescens 的 Daphniphyllum 生物碱。


Glaulalactams AC (1-3) 具有新颖的骨架，以及已知的化合物 daphmanidin B (4)，是从 Daphniphyllum glucescens 的叶子中分离出来的，并使用离子交换色谱法和 NMR 指纹图谱辅助进行分离。通过光谱分析和时间相关的密度泛函理论计算的电子圆二色光谱阐明了它们的结构，包括它们的绝对构型；随后对数据进行分析，以深入了解分离株之间各自的生物遗传关系，这些分离株表现出抗 H1N1 流感和免疫抑制活性。