Porphyrinic Metal–Organic Framework PCN-224 Nanoparticles for Near-Infrared-Induced Attenuation of Aggregation and Neurotoxicity of Alzheimer’s Amyloid-β Peptide,ACS Applied Materials & Interfaces

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Porphyrinic Metal–Organic Framework PCN-224 Nanoparticles for Near-Infrared-Induced Attenuation of Aggregation and Neurotoxicity of Alzheimer’s Amyloid-β Peptide
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2018-10-17 00:00:00 , DOI: 10.1021/acsami.8b15452
Jiuhai Wang ₁ , Yadi Fan ₁ , Youhua Tan ₁ , Xin Zhao ₁ , Yu Zhang ₂ , Changming Cheng ₁ , Mo Yang ₁

Affiliation

The aberrant aggregation of amyloid-β peptide (Aβ) in the brain has been considered as the major pathological hallmark of Alzheimer’s diseases (AD). Inhibition of Aβ aggregation is considered as an attractive therapeutic intervention for alleviating amyloid-associated neurotoxicity. Here, we report the near-infrared light (NIR)-induced suppression of Aβ aggregation and reduction of Aβ-induced cytotoxicity via porphyrinic metal–organic framework (MOF) PCN-224 nanoparticles. PCN-224 nanoparticles are hydrothermally synthesized by coordinating tetra-kis(4-carboxyphenyl)porphyrin (TCPP) ligands with zirconium. The PCN-224 nanoparticles show high photo-oxygenation efficiency, good biocompatibility, and high stability. The study reveals that the porphyrinic MOF-based nanoprobe activated by NIR light could successfully inhibit self-assembly of monomeric Aβ into a β-sheet-rich structure. Furthermore, photoexcited PCN-224 nanoparticles also significantly reduce Aβ-induced cytotoxicity under NIR irradiation.

中文翻译：

卟啉金属有机骨架PCN-224纳米粒子对阿尔茨海默氏症β淀粉样肽的聚集和神经毒性的衰减

大脑中淀粉样β肽（Aβ）的异常聚集被认为是阿尔茨海默氏病（AD）的主要病理标志。抑制Aβ聚集被认为是减轻淀粉样蛋白相关的神经毒性的有吸引力的治疗性干预。在这里，我们报告通过卟啉金属-有机骨架（MOF）PCN-224纳米粒子，近红外（NIR）诱导的Aβ聚集抑制和Aβ诱导的细胞毒性降低。通过将四（4-羧基苯基）卟啉（TCPP）配体与锆配位，水热合成PCN-224纳米粒子。PCN-224纳米颗粒显示出高的光氧合效率，良好的生物相容性和高稳定性。研究表明，由近红外光激活的基于卟啉MOF的纳米探针可以成功抑制单体Aβ自组装成富含β-折叠的结构。此外，光激发的PCN-224纳米颗粒在NIR照射下也显着降低了Aβ诱导的细胞毒性。

更新日期：2018-10-17

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