BATLAS：对棕色脂肪组织进行去卷积。,Cell Reports

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BATLAS：对棕色脂肪组织进行去卷积。
Cell Reports ( IF 7.5 ) Pub Date : 2018-10-16 , DOI: 10.1016/j.celrep.2018.09.044
Aliki Perdikari ₁ , Germán Gastón Leparc ₂ , Miroslav Balaz ₁ , Nuno D Pires ₁ , Martin E Lidell ₃ , Wenfei Sun ₁ , Francesc Fernandez-Albert ₂ , Sebastian Müller ₁ , Nassila Akchiche ₁ , Hua Dong ₁ , Lucia Balazova ₁ , Lennart Opitz ₁ , Eva Röder ₁ , Holger Klein ₂ , Patrik Stefanicka ₄ , Lukas Varga ₅ , Pirjo Nuutila ₆ , Kirsi A Virtanen ₆ , Tarja Niemi ₇ , Markku Taittonen ₈ , Gottfried Rudofsky ₉ , Jozef Ukropec ₁₀ , Sven Enerbäck ₃ , Elia Stupka ₂ , Heike Neubauer ₁₁ , Christian Wolfrum ₁

Affiliation

Institute of Food, Nutrition and Health, ETH Zurich, Schwerzenbach, Switzerland.
Target Discovery Research Department, Boehringer Ingelheim Pharma GmbH and Co. KG, Biberach/Riss, Germany.
Department of Medical and Clinical Genetics, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Department of Otorhinolaryngology - Head and Neck Surgery, Faculty of Medicine and University Hospital, Comenius University, Bratislava, Slovakia.
Department of Otorhinolaryngology - Head and Neck Surgery, Faculty of Medicine and University Hospital, Comenius University, Bratislava, Slovakia; Institute of Experimental Endocrinology, Biomedical Research Center at the Slovak Academy of Sciences, Bratislava, Slovakia.
Turku PET Centre, University of Turku, Turku, Finland.
Department of Surgery, Turku University Hospital, Turku, Finland.
Department of Anesthesiology, Turku University Hospital, Turku, Finland.
Endocrinology and Metabolic Diseases, Cantonal Hospital Olten, Olten, Switzerland.
Institute of Experimental Endocrinology, Biomedical Research Center at the Slovak Academy of Sciences, Bratislava, Slovakia.
Cardiometabolic Diseases Research Department, Boehringer Ingelheim Pharma GmbH and Co. KG, Biberach/Riss, Germany.

作为改善全身代谢控制的策略，热源脂肪细胞的招募和激活已受到越来越多的关注。脂肪组织活检的复杂性使棕色和棕色脂肪细胞的分析变得复杂。在这里，我们提供了对纯棕色，棕色和白色脂肪细胞转录组的深入分析。通过结合小鼠和人类的转录组数据，我们确定了可以对小鼠和男人的棕色和白色脂肪细胞进行分类的基因签名。使用基于机器学习的细胞反卷积方法，我们开发了一种算法，可以熟练地计算复杂的人和小鼠活检组织中棕色脂肪细胞的含量。应用此算法，我们可以在一项人体减肥研究中证明，棕色脂肪组织（BAT）的含量与能量消耗和减肥的倾向有关。

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更新日期：2018-10-17

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