Near-infrared (NIR) fluorescent sensors have been actively pursued due to organisms exhibiting little autofluorescence in near-infrared regions. Capable of emitting luminesence under 980 nm excitation, upconversion nanoparticles have shown promise as optical agents for in vivo bioimaging. Based on luminescence resonance energy transfer (LRET), a NIR luminescent Arg-nanoprobe was developed by the decoration of upconversion nanoparticles (UCNPs) (NaYF₄:Yb,Er) with organic molecules. The as-developed nanoprobe could quantitatively detect concentrations within the range of 528–1250 μM, and had high sensitiviy (the limit of detection, LOD, being 15.6 μM) and good photostability. Because the probe could target lysosomes, intracellar detection of Arg behavior was demonstrated via upconversion luminescence (UCL) imaging.

由于生物体在近红外区域显示很少的自发荧光，因此近来一直在积极寻求近红外（NIR）荧光传感器。能够在980 nm激发下发射发光的上转换纳米粒子已显示出有望用作体内生物成像的光学试剂。基于发光共振能量转移（LRET），通过上转换纳米粒子（UCNPs）（NaYF ₄）的装饰开发了NIR发光的Arg-纳米探针。：Yb，Er）与有机分子。所开发的纳米探针可以定量检测528–1250μM范围内的浓度，并且灵敏度高（检测极限LOD为15.6μM），并且具有良好的光稳定性。因为该探针可以靶向溶酶体，所以通过上转换发光（UCL）成像证明了细胞内Arg行为的检测。