Direct catalytic asymmetric vinylogous reaction serves as a powerful tool to introduce stereocenter(s) at the γ- or/and even more remote position(s) of the vinylogous products in an atom-economical and efficient way. A variety of direct catalytic asymmetric vinylogous reactions with broad substrate scope and mild reaction conditions has been developed. Both metal catalysis and organocatalysis contributed in this field and led to the vinylogous products in high stereoselectivity. These vinylogous reactions provided efficient pathways for the synthesis of highly functionalized optically pure compounds, especially these with potential biological activity and pharmacological activity. This digest paper mainly focuses on the most recent developments in this field, including both nucleophilic addition and nucleophilic substitution.

直接催化的不对称乙烯基反应是一种功能强大的工具，可以原子经济且有效的方式在乙烯基产物的γ-或/和甚至更远的位置引入立体中心。已经开发了具有广泛的底物范围和温和的反应条件的多种直接催化不对称乙烯基反应。金属催化和有机催化都在该领域做出了贡献，并导致了具有高立体选择性的乙烯基产物。这些乙烯基反应为合成高度官能化的光学纯化合物，特别是具有潜在生物学活性和药理活性的化合物提供了有效的途径。本摘要文章主要关注该领域的最新进展，包括亲核加成和亲核取代。