A Method for Synthesis of 3-Hydroxy-1-indanones via Cu-Catalyzed Intramolecular Annulation Reactions,The Journal of Organic Chemistry

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A Method for Synthesis of 3-Hydroxy-1-indanones via Cu-Catalyzed Intramolecular Annulation Reactions
The Journal of Organic Chemistry ( IF 3.3 ) Pub Date : 2018-10-08 00:00:00 , DOI: 10.1021/acs.joc.8b02149
Guoxue He ₁ , Chenglin Wu ₂ , Jianhui Zhou ₂ , Qiaolan Yang ₂ , Chunmei Zhang ₂ , Yu Zhou ₂ , Huabei Zhang ₁ , Hong Liu ₂

Affiliation

We report a facile and highly efficient method that copper-catalyzed intramolecular annulation to synthesize 3-hydroxy-1-indanones employing simple 2-ethynylbenzaldehyde as starting materials was achieved successfully. This protocol provided a simple synthetic approach to afford 3-hydroxy-1-indanones under mild conditions in good to excellent yields.

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