Synthetic polymers have had a major impact on the biomedical field. However, all polymers have their advantages and disadvantages, so that the selection of a certain polymeric material always is a compromise with regard to many properties, such as synthetic accessibility, solubility, thermal properties, biocompatibility, and degradability. The development of novel polymers with superior properties for medical applications is the focus of many research groups. The present study highlights the use of poly(2-isopropenyl-2-oxazoline) (PiPOx), as biocompatible functional polymer to develop synthetic hydrogel materials using a simple straightforward synthesis protocol. A library of hydrogels was obtained by chemical cross-linking of PiPOx, using eight different nontoxic and bio-based dicarboxylic acids. The equilibrium swelling degree of the final material can be modulated by simple modification of the composition of the reaction mixture, including the polymer concentration in the feed ratio between the 2-oxazoline pendent groups and the carboxylic acid groups as well as the cross-linker length. The hydrogels with the highest water uptake were selected for further investigations regarding their potential use as biomaterials. We evaluated the thermoresponsiveness, the pH degradability under physiological conditions, and demonstrated proof-of-concept drug delivery experiments. The in vitro cellular studies demonstrated the noncytotoxic character of the PiPOx hydrogels, and their protein repellent properties, while mineralization studies revealed that such scaffolds do not promote mineralization/calcification phenomena. In view of these results, these hydrogels show potential use as ophthalmologic materials or in drug delivery applications.

中文翻译：

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用于生物医学的聚（2-异丙烯基-2-恶唑啉）水凝胶

合成聚合物对生物医学领域产生了重大影响。但是，所有聚合物都有其优点和缺点，因此，某些聚合材料的选择始终是许多特性（例如合成可及性，溶解性，热特性，生物相容性和可降解性）的折衷方案。具有优异性能的新型聚合物在医学应用中的开发是许多研究小组的重点。本研究强调了使用聚（2-异丙烯基-2-恶唑啉）（PiPOx）作为生物相容性功能聚合物，可使用简单直接的合成方案开发合成水凝胶材料。使用八种不同的无毒和生物基二羧酸，通过PiPOx的化学交联获得了水凝胶库。可以通过简单地改变反应混合物的组成来调节最终材料的平衡溶胀度，包括改变2-恶唑啉侧基和羧酸基团之间进料比中的聚合物浓度以及交联剂的长度。 。选择了吸水率最高的水凝胶，以进一步研究其作为生物材料的潜在用途。我们评估了在生理条件下的热响应性，pH降解性，并证明了概念验证的药物传递实验。这 选择吸水率最高的水凝胶，以进一步研究其作为生物材料的潜在用途。我们评估了在生理条件下的热响应性，pH降解性，并证明了概念验证的药物传递实验。这 选择了吸水率最高的水凝胶，以进一步研究其作为生物材料的潜在用途。我们评估了在生理条件下的热响应性，pH降解性，并证明了概念验证的药物传递实验。这体外细胞研究证明了PiPOx水凝胶的非细胞毒性特性及其蛋白排斥特性，而矿化研究表明此类支架不会促进矿化/钙化现象。鉴于这些结果，这些水凝胶显示出潜在的用途，可作为眼科材料或在药物递送应用中使用。