The metoprolol fumarate (MF) salt has been characterized by a combined use of powder X-ray diffraction (PXRD), variable temperature PXRD (VT-PXRD), and differential scanning calorimetry. Its molecular and crystal structure, as determined from PXRD data, has been thoroughly compared to those of the analogous tartrate (MT-o) and succinate (MS-m) salts. Moreover, Hirshfeld surface analysis and graph sets analysis have been performed to achieve insights into the intermolecular interactions. Despite their evident similarities at the molecular level, the three salts behave differently upon temperature variation: MF expands/contracts anisotropically (as MS-m), but the melt takes 3 days to recover the starting crystalline phase (as MT-o). A rationale for this behavior is provided based on their crystal arrangements.

中文翻译：

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富马酸麦特洛尔：粉末X射线衍射数据的晶体结构以及与酒石酸盐和琥珀酸盐的比较

富马酸美托洛尔（MF）盐的特征是结合使用粉末X射线衍射（PXRD），可变温度PXRD（VT-PXRD）和差示扫描量热法。根据PXRD数据确定，其分子和晶体结构已与类似酒石酸盐（MT-o）和琥珀酸盐（MS-m）的盐进行了彻底比较。此外，已进行了Hirshfeld表面分析和图形集分析，以深入了解分子间的相互作用。尽管它们在分子水平上具有明显的相似性，但三种盐在温度变化时的行为却有所不同：MF各向异性地膨胀/收缩（如MS-m），但熔体需要3天才能恢复起始结晶相（如MT-o）。根据其晶体排列，提供了此行为的基本原理。