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Light-Activated Nanoprobes for Biosensing and Imaging.
Advanced Materials ( IF 27.4 ) Pub Date : 2018-10-01 , DOI: 10.1002/adma.201804745 Mengyuan Li 1, 2 , Jian Zhao 1 , Hongqian Chu 1 , Yongsheng Mi 1 , Zehao Zhou 1 , Zhenghan Di 1 , Meiping Zhao 2 , Lele Li 1
Advanced Materials ( IF 27.4 ) Pub Date : 2018-10-01 , DOI: 10.1002/adma.201804745 Mengyuan Li 1, 2 , Jian Zhao 1 , Hongqian Chu 1 , Yongsheng Mi 1 , Zehao Zhou 1 , Zhenghan Di 1 , Meiping Zhao 2 , Lele Li 1
Affiliation
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Fluorescent nanoprobes are indispensable tools to monitor and analyze biological species and dynamic biochemical processes in cells and living bodies. Conventional nanoprobes have limitations in obtaining imaging signals with high precision and resolution because of the interference with biological autofluorescence, off-target effects, and lack of spatiotemporal control. As a newly developed paradigm, light-activated nanoprobes, whose imaging and sensing activity can be remotely regulated with light irradiation, show good potential to overcome these limitations. Herein, recent research progress on the design and construction of light-activated nanoprobes to improve bioimaging and sensing performance in complex biological systems is introduced. First, recent innovative strategies and their underlying mechanisms for light-controlled imaging are reviewed, including photoswitchable nanoprobes and phototargeted nanosystems. Subsequently, a short highlight is provided on the development of light-activatable nanoprobes for biosensing, which offer possibilities for the remote control of biorecognition and sensing activity in a precise manner both temporally and spatially. Finally, perspectives and challenges in light-activated nanoprobes are commented.
中文翻译：
用于生物传感和成像的光活化纳米探针。
荧光纳米探针是监测和分析细胞和活体内生物物种和动态生化过程必不可少的工具。由于干扰生物自发荧光，脱靶效应和缺乏时空控制，常规的纳米探针在获得高精度和高分辨率的成像信号方面存在局限性。作为一种新开发的范例，光激活纳米探针的成像和传感活性可以通过光辐射进行远程调节，显示出克服这些局限性的良好潜力。在此，介绍了用于改善复杂生物系统中的生物成像和传感性能的光活化纳米探针的设计和构建的最新研究进展。第一的，综述了光控制成像的最新创新策略及其潜在机理，包括光可切换纳米探针和光靶向纳米系统。随后，简要介绍了用于生物传感的可光激活纳米探针的发展，这为在时间和空间上以精确的方式远程控制生物识别和传感活动提供了可能性。最后，评论了光激活纳米探针的观点和挑战。
更新日期：2019-11-06
中文翻译：
用于生物传感和成像的光活化纳米探针。
荧光纳米探针是监测和分析细胞和活体内生物物种和动态生化过程必不可少的工具。由于干扰生物自发荧光，脱靶效应和缺乏时空控制，常规的纳米探针在获得高精度和高分辨率的成像信号方面存在局限性。作为一种新开发的范例，光激活纳米探针的成像和传感活性可以通过光辐射进行远程调节，显示出克服这些局限性的良好潜力。在此，介绍了用于改善复杂生物系统中的生物成像和传感性能的光活化纳米探针的设计和构建的最新研究进展。第一的，综述了光控制成像的最新创新策略及其潜在机理，包括光可切换纳米探针和光靶向纳米系统。随后，简要介绍了用于生物传感的可光激活纳米探针的发展，这为在时间和空间上以精确的方式远程控制生物识别和传感活动提供了可能性。最后，评论了光激活纳米探针的观点和挑战。
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