Size-Controlled Synthesis of Sub-10-nanometer Citrate-Stabilized Gold Nanoparticles and Related Optical Properties.,Chemistry of Materials

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Size-Controlled Synthesis of Sub-10-nanometer Citrate-Stabilized Gold Nanoparticles and Related Optical Properties.
Chemistry of Materials ( IF 7.2 ) Pub Date : 2016-02-08 00:00:00 , DOI: 10.1021/acs.chemmater.5b04406
Jordi Piella _{1,

2} , Neus G. Bastús ₁ , Victor Puntes _{1,

3,

4}

Affiliation

Highly monodisperse, biocompatible and functionalizable sub-10-nm citrate-stabilized gold nanoparticles (Au NPs) have been synthesized following a kinetically controlled seeded-growth strategy. The use of traces of tannic acid together with an excess of sodium citrate during nucleation is fundamental in the formation of a high number (7 × 10¹³ NPs/mL) of small ∼3.5 nm Au seeds with a very narrow distribution. A homogeneous nanometric growth of these seeds is then achieved by adjusting the reaction parameters: pH, temperature, sodium citrate concentration and gold precursor to seed ratio. We use this method to produce Au NPs with a precise control over their sizes between 3.5 and 10 nm and a versatile surface chemistry allowing studying the size-dependent optical properties in this transition size regime lying between clusters and nanoparticles. Interestingly, an inflection point is observed for Au NPs smaller than 8 nm in which the sensitivity of the localized surface plasmon resonance (LSPR) peak position as a function of NPs size and surface modifications dramatically increase. These studies are relevant in the design of the final selectivity, activity and compatibility of Au NPs, especially in those (bio)applications where size is a critical parameter (e.g., biodistribution, multiplex labeling, and protein interaction).

中文翻译：

亚10纳米柠檬酸盐稳定的金纳米粒子的尺寸控制合成及其相关的光学性能。

遵循动力学控制的种子生长策略，已经合成了高度单分散，生物相容且可功能化的亚10纳米以下柠檬酸盐稳定的金纳米颗粒（Au NPs）。成核过程中使用痕量的单宁酸和过量的柠檬酸钠是形成大量（7×10 ¹³NPs / mL）〜3.5 nm的小Au种子，分布非常狭窄。然后，通过调节反应参数：pH，温度，柠檬酸钠浓度和金前体与种子的比例，可以实现这些种子的均匀纳米级生长。我们使用这种方法来生产Au纳米粒子，其尺寸精确控制在3.5到10 nm之间，并且具有通用的表面化学性质，从而可以研究簇和纳米粒子之间在此过渡尺寸范围内依赖尺寸的光学性质。有趣的是，对于小于8 nm的Au NP，观察到拐点，其中局部表面等离振子共振（LSPR）峰位置的灵敏度随NP大小和表面修饰而显着增加。这些研究与Au NP的最终选择性，活性和相容性的设计有关，

更新日期：2016-02-08

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