The cover picture shows two one-pot processes for the bioenzymatic synthesis of ethyl (R)-3-hydroxyglutarate (EHG), a key intermediate for the synthesis of rosuvastatin, from ethyl (S)-4-chloro-3-hydroxybutyrate (ECHB). In their Full Paper Q. Wu, D. Zhu and co-workers show how in a one-pot two-step process the intermediate ethyl (R)-4-cyano-3-hydroxybutyate (HN) can be synthesized by using Escherichia coli cells expressing a halohydrin dehalogenase gene, followed by hydrolysis to EHG with Escherichia coli cells expressing a nitrilase gene. The recombinant Escherichia coli cells co-expressing halohydrin dehalogenase and nitrilase genes can be used in a one-pot one-step process to produce EHG directly. The article highlighted by this cover can be found on p. 1438 ff. of Issue 9, 2015.

中文翻译：

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封面图片

封面图片显示了从（S）-4-氯-3-羟基丁酸乙酯（ECHB）合成瑞舒伐他汀的关键中间体的两个单锅法，用于生物酶法合成（R）-3-羟基戊二酸乙酯（EHG）。）。在他们的论文Q. Wu，D。Zhu和他们的同事中，他们展示了如何在一锅两步过程中利用大肠杆菌来合成中间体（R）-4-氰基-3-羟基丁酸乙酯（HN）细胞中表达卤代醇脱卤酶基因，随后将其水解EHG与大肠杆菌细胞中表达一个腈水解酶基因。重组大肠杆菌共表达卤代醇脱卤酶和腈水解酶基因的细胞可用于一锅一步骤的过程中直接产生EHG。此封面突出显示的文章可以在第23页上找到。1438及以后 2015年第9期。