Functional Nanomaterials and Nanostructures Enhancing Electrochemical Biosensors and Lab-on-a-Chip Performances: Recent Progress, Applications, and Future Perspective,Chemical Reviews

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Functional Nanomaterials and Nanostructures Enhancing Electrochemical Biosensors and Lab-on-a-Chip Performances: Recent Progress, Applications, and Future Perspective
Chemical Reviews ( IF 51.4 ) Pub Date : 2018-09-24 00:00:00 , DOI: 10.1021/acs.chemrev.8b00172
Nongnoot Wongkaew ₁ , Marcel Simsek ₁ , Christian Griesche ₁ , Antje J. Baeumner ₁

Affiliation

Electrochemical biosensors and associated lab-on-a-chip devices are the analytical system of choice when rapid and on-site results are needed in medical diagnostics and food safety, for environmental protection, process control, wastewater treatment, and life sciences discovery research among many others. A premier example is the glucose sensor used by diabetic patients. Current research focuses on developing sensors for specific analytes in these application fields and addresses challenges that need to be solved before viable commercial products can be designed. These challenges typically include the lowering of the limit of detection, the integration of sample preparation into the device and hence analysis directly within a sample matrix, finding strategies for long-term in vivo use, etc. Today, functional nanomaterials are synthesized, investigated, and applied in electrochemical biosensors and lab-on-a-chip devices to assist in this endeavor. This review answers many questions around the nanomaterials used, their inherent properties and the chemistries they offer that are of interest to the analytical systems, and their roles in analytical applications in the past 5 years (2013–2018), and it gives a quantitative assessment of their positive effects on the analyses. Furthermore, to facilitate an insightful understanding on how functional nanomaterials can be beneficial and effectively implemented into electrochemical biosensor-based lab-on-a-chip devices, seminal studies discussing important fundamental knowledge regarding device fabrication and nanomaterials are comprehensively included here. The review ultimately gives answers to the ultimate question: “Are they really needed or can bulk materials accomplish the same?” Finally, challenges and future directions are also discussed.

中文翻译：

增强电化学生物传感器和芯片实验室性能的功能纳米材料和纳米结构：最新进展，应用和未来展望

当需要在医学诊断和食品安全，环境保护，过程控制，废水处理和生命科学发现研究中需要快速而现场的结果时，电化学生物传感器和相关的芯片实验室设备是首选的分析系统很多其他的。一个典型的例子是糖尿病患者使用的葡萄糖传感器。当前的研究重点是在这些应用领域中开发用于特定分析物的传感器，并解决在设计可行的商业产品之前需要解决的挑战。这些挑战通常包括降低检测限，将样品前处理集成到设备中，从而直接在样品基质中进行分析，寻找长期体内使用的策略等。今天，功能纳米材料已经被合成，进行了研究，并应用于电化学生物传感器和片上实验室设备中，以协助实现这一目标。这篇评论回答了有关所用纳米材料，其固有性质和所提供的化学分析系统感兴趣的许多问题，以及它们在过去五年（2013-2018年）中在分析应用中的作用，并给出了定量评估对分析的积极影响。此外，为了促进对功能纳米材料如何有益和有效实施到基于电化学生物传感器的芯片实验室设备的深入了解，这里全面讨论了有关器件制造和纳米材料的重要基础知识的开创性研究。该评论最终给出了最终问题的答案：“他们真的需要吗？还是散装材料可以做到这一点？” 最后，还讨论了挑战和未来方向。

更新日期：2018-09-24

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