A novel series of melanin concentrating hormone receptor 1 (MCHr1) antagonists were the starting point for a drug discovery program that culminated in the discovery of 103 (AZD1979). The lead optimization program was conducted with a focus on reducing lipophilicity and understanding the physicochemical properties governing CNS exposure and undesired off-target pharmacology such as hERG interactions. An integrated approach was taken where the key assay was ex vivo receptor occupancy in mice. The candidate compound 103 displayed appropriate lipophilicity for a CNS indication and showed excellent permeability with no efflux. Preclinical GLP toxicology and safety pharmacology studies were without major findings and 103 was taken into clinical trials.

中文翻译：

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发现（3-（4-（2-Oxa-6-氮杂螺[3.3]庚-6-基甲基）苯氧基）氮杂环丁烷-1-基）（5-（4-甲氧基苯基）-1,3,4-恶二唑- 2-基）甲酮（AZD1979），具有良好理化特性的黑色素浓缩激素受体1（MCHr1）拮抗剂。

一系列新的黑色素浓缩激素受体1（MCHr1）拮抗剂是药物发现计划的起点，该计划最终发现了103（AZD1979）。进行前导优化程序的重点是降低亲脂性并了解控制CNS暴露和不期望的脱靶药理作用（例如hERG相互作用）的理化性质。采取了一种综合方法，其中关键测定是小鼠体内离体受体的占有率。候选化合物103对于CNS适应症表现出适当的亲脂性，并且显示出优异的渗透性而没有外排。临床前GLP毒理学和安全药理学研究无重大发现，有103例被纳入临床试验。