Synthesis ( IF 2.2 ) Pub Date : 2018-09-17 , DOI: 10.1055/s-0037-1610907
Deqing Shi 1 , Lingna Wang , Tiancong Ma , Mingming Qiao , Qiangxian Wu , Wenjing Xiao
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Abstract
A visible-light photoredox-catalyzed oxidation/[3+2] cycloaddition/oxidative aromatization cascade reaction of [(3,4-dihydroisoquinolin-2(1H)-yl)methyl]phosphonates and activated olefins or alkynes for the efficient synthesis of potentially biological active pyrrolo[2,1-a]isoquinoline-substituted phosphonates was developed. This transformation features mild reaction conditions (i.e., visible light irradiation, room temperature), molecular oxygen (O2) as a green oxidant, simple ‘one-pot’ operation.
A visible-light photoredox-catalyzed oxidation/[3+2] cycloaddition/oxidative aromatization cascade reaction of [(3,4-dihydroisoquinolin-2(1H)-yl)methyl]phosphonates and activated olefins or alkynes for the efficient synthesis of potentially biological active pyrrolo[2,1-a]isoquinoline-substituted phosphonates was developed. This transformation features mild reaction conditions (i.e., visible light irradiation, room temperature), molecular oxygen (O2) as a green oxidant, simple ‘one-pot’ operation.
中文翻译：
可见光光催化氧化级联反应合成吡咯并[2,1-a]异喹啉取代的膦酸酯
摘要
[（3,4-二氢异喹啉-2（1 H）-基）甲基]膦酸酯和活化的烯烃或炔烃的可见光光氧化还原催化的氧化/ [3 + 2]环加成/氧化芳构化级联反应开发了具有潜在生物活性的吡咯并[2，1 - a ]异喹啉取代的膦酸酯。这种转化具有温和的反应条件（即可见光辐射，室温），分子氧（O 2）作为绿色氧化剂，简单的“一锅法”操作。
[（3,4-二氢异喹啉-2（1 H）-基）甲基]膦酸酯和活化的烯烃或炔烃的可见光光氧化还原催化的氧化/ [3 + 2]环加成/氧化芳构化级联反应开发了具有潜在生物活性的吡咯并[2，1 - a ]异喹啉取代的膦酸酯。这种转化具有温和的反应条件（即可见光辐射，室温），分子氧（O 2）作为绿色氧化剂，简单的“一锅法”操作。
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