Lyotropic non-lamellar liquid crystalline (LLC) nanoparticles are attractive nanocarriers for drug delivery, particularly for the solubilization of poorly water-soluble drugs. Due to the reported problems of complement activation and cytotoxicity of most investigated Pluronic F127-stabilized cubosomes and hexosomes, there is an interest in introducing safe stabilizers for these LLC nanodispersions. Citrem appears to be the stabilizer of choice for the colloidal stabilization of these LLC nano-self-assemblies owing to its hemocompatiblity and poor activation of the complement system. This anionic food-grade emulsifier in combination with soy phosphatidylcholine (SPC) can be used to introduce a library of hemocompatible lamellar and non-lamellar liquid crystalline nanodispersions at different lipid compositions. We found that batch-to-batch variability in citrem composition is associated with slight alterations in the size, structural characteristics, and surface charge of the produced citrem/SPC nanoparticles. Further, we report on the temperature-triggered alterations in these nano-self-assemblies at different lipid compositions by using synchrotron small angle X-ray scattering (SAXS). The addition of citrem at different temperatures induces lamellar to non-lamellar structural transitions as evident from the appearance of inverse bicontinuous cubic Pn3m and discontinuous hexagonal (H₂) phases, respectively, upon increasing citrem concentration and varying temperature in the range of 5–59 °C. Citrem/SPC nanoparticles are attractive for use in the development of nanocarriers for drug delivery owing to their structural tunability and hemocompatiblity.

溶致性非层状液晶（LLC）纳米颗粒是用于药物输送的引人注目的纳米载体，特别是用于水溶性差的药物的增溶。由于报告的大多数研究过的Pluronic F127稳定的立方脂质体和六脂质体的补体激活和细胞毒性问题，因此有兴趣为这些LLC纳米分散体引入安全的稳定剂。由于其血液相容性和补体系统活化不良，因此Citrem似乎是这些LLC纳米自组装胶体稳定化的首选稳定剂。该阴离子食品级乳化剂与大豆磷脂酰胆碱（SPC）结合可用于在不同脂质组成下引入可与血液相容的层状和非层状液晶纳米分散体的库。我们发现，柑桔成分的批次间差异与所产生的柑桔/ SPC纳米粒子的大小，结构特征和表面电荷的轻微变化有关。此外，我们通过使用同步加速器小角度X射线散射（SAXS）报告了在不同脂质成分下这些纳米自组装中的温度触发变化。从反双连续立方的出现可以明显看出，在不同温度下加入柑桔会诱导层状到非层状的结构转变。我们通过使用同步加速器小角度X射线散射（SAXS）报告了这些纳米自组装在不同脂质成分下的温度触发变化。从反双连续立方的出现可以明显看出，在不同温度下加入柑桔会诱导层状到非层状的结构转变。我们通过使用同步加速器小角度X射线散射（SAXS）报告了在不同脂质成分下这些纳米自组装体的温度触发变化。从反双连续立方的出现可以明显看出，在不同温度下加入柑桔会诱导层状到非层状的结构转变。随着柑桔浓度的增加和温度在5–59°C范围内的变化，Pn3m相和不连续六方（H ₂）相分别出现。由于其结构可调性和血液相容性，Citrem / SPC纳米颗粒在开发用于药物输送的纳米载体方面具有吸引力。