The purpose of this research is to arouse people's cognition of the dual role of Bletilla striata polysaccharide (BSP)—a kind of biocompatible, biodegradable natural biological materials with myriad pharmacological activities. BSP was extracted and characterized firstly. The results indicated that BSP was composed of mannose and glucose. The backbone of BSP mainly consisted of (1 → 4)-linked β-D-mannopyranose. Afterwards, A 3² factorial design was employed for optimization of lyophilized wafers for the treatment of traumatic oral ulcer with concentrations of BSP and glycerin as independent variables. Tensile strength, mucoadhesive strength, and swelling index were measured as response variables. It was determined that the wafer prepared from a solution containing 4% (w/v) BSP and 7% (w/v) glycerin was the optimal formulation. The wafers exhibited sufficient mechanical strength and suitable surface pH. Morphology of the wafers was observed. DSC/TGA thermograms showed the presence of three peaks weight loss events and decomposition patterns. Moreover, in vivo examinations indicated that the BSP wafer significantly promoted ulcer healing at 7 days, while no statistically significant difference was observed on day 12. In conclusion, this study suggests that BSP is an ideal biomaterial for mucosal adhesion agents, playing a nontrivial role in promoting oral ulcer healing.

这项研究的目的是唤起人们对白let多糖（BSP）双重作用的认识，白SP多糖是一种具有多种药理活性的生物相容性，可生物降解的天然生物材料。首先提取并表征了BSP。结果表明BSP由甘露糖和葡萄糖组成。BSP的骨架主要由（1→4）连接的β-D-甘露吡喃糖组成。之后，A 3 ²因子设计被用于冻干薄饼的优化，以BSP和甘油的浓度作为自变量来治疗创伤性口腔溃疡。测量拉伸强度，粘膜粘附强度和溶胀指数作为响应变量。确定由包含4％（w / v）BSP和7％（w / v）甘油的溶液制备的威化饼是最佳配方。晶片表现出足够的机械强度和合适的表面pH。观察晶片的形态。DSC / TGA热分析图显示存在三个峰值失重事件和分解模式。此外，体内检查表明BSP薄饼在7天时可显着促进溃疡愈合，而在第12天时未观察到统计学上的显着差异。