Synthesis, Secondary Structure, and Anion Binding of Acyclic Carbohydrate‐Derived Oligo(amide‐triazole)s,European Journal of Organic Chemistry

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Synthesis, Secondary Structure, and Anion Binding of Acyclic Carbohydrate‐Derived Oligo(amide‐triazole)s
European Journal of Organic Chemistry ( IF 2.5 ) Pub Date : 2018-11-14 , DOI: 10.1002/ejoc.201801320
Daniela M. Fidalgo _{1,

2} , María Eugenia Monge ₃ , Oscar Varela _{1,

2} , Adriana A. Kolender _{1,

2}

Affiliation

Linear sugar‐derived oligo(amide‐triazole)s with one (dimer) to four (pentamer) carbohydrate and triazole units act as halide receptors. The binding affinities for the tetramers and pentamers follow the order Cl^– > Br^– > I^–. The pentamer adopts a helix conformation, slightly distorted by chloride. The active site in the pentamer backbone involves the triazole‐CH, amide‐NH, and H‐4′ from the carbohydrate residue.

中文翻译：

无环碳水化合物衍生的寡（酰胺-三唑）s的合成，二级结构和阴离子结合

线性糖衍生的低聚（酰胺三唑）具有一个（二聚体）至四个（戊二烯）碳水化合物和三唑单元，可作为卤化物受体。四聚体和五聚体的结合亲和力遵循Cl ^– > Br ^– > I ^–的顺序。五聚体采用螺旋构象，略微受氯化物扭曲。五聚体骨架中的活性位点涉及碳水化合物残基中的三唑-CH，酰胺-NH和H-4'。

更新日期：2018-11-14

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