Bisphenol A (BPA) has been used in the plastics industry for several decades. During the treatment of drinking water with chlorine reagent, the formation of chlorinated derivatives of BPA (ClxBPA) but also bromoBPA and bromochloroBPA is to be expected. Some of these compounds are considered to have an estrogenic effect and could induce major risks for human health by targeting different organs and systems in the body. In this paper, we describe the synthesis of chloro- and bromobisphenol A (ClxBPA, BrxBPA, BrxClxBPA)and their analytical characterization. These derivatives could be used as analytical standards in LC-MS/MS or evaluated in in vitro biological tests for their potential as endocrine disruptors. In this study, we evaluated the presence of BPA, ClxBPA in a pilot study from water samples. Range values found for BPA, ClxBPA were respectively 2.8–4169.3 ng/L and 0.8–11.3 ng/L.

双酚A（BPA）已在塑料工业中使用了数十年。在用氯试剂处理饮用水的过程中，预计会形成BPA的氯化衍生物（ClxBPA），而且还会形成bromoBPA和bromochloroBPA。这些化合物中的某些被认为具有雌激素作用，并且可能通过靶向体内的不同器官和系统而对人类健康造成重大风险。在本文中，我们描述了氯和溴双酚A（ClxBPA，BrxBPA，BrxClxBPA）的合成及其分析特性。这些衍生物可用作LC-MS / MS中的分析标准品或体外评估对其潜在的内分泌干扰物进行生物学测试。在这项研究中，我们在来自水样的初步研究中评估了BPA，ClxBPA的存在。BPA，ClxBPA的范围值分别为2.8–4169.3 ng / L和0.8–11.3 ng / L。