Ultratough, Self-Healing, and Tissue-Adhesive Hydrogel for Wound Dressing,ACS Applied Materials & Interfaces

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Ultratough, Self-Healing, and Tissue-Adhesive Hydrogel for Wound Dressing
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2018-09-11 00:00:00 , DOI: 10.1021/acsami.8b10064
Tao Chen ₁ , Yujie Chen ₁ , Hafeez Ur Rehman ₁ , Zhen Chen ₁ , Zhi Yang ₂ , Man Wang ₁ , Hua Li ₁ , Hezhou Liu ₁

Affiliation

A hydrogel for potential applications in wound dressing should possess several peculiar properties, such as efficient self-healing ability and mechanical toughness, so as to repair muscle and skin damage. Additionally, excellent cell affinity and tissue adhesiveness are also necessary for the hydrogel to integrate with the wound tissue in practical applications. Herein, an ultratough and self-healing hydrogel with superior cell affinity and tissue adhesiveness is prepared. The self-healing ability of the hydrogel is obtained through hydrogen bonds and dynamic Schiff cross-linking between dopamine-grafted oxidized sodium alginate (OSA-DA) and polyacrylamide (PAM) chains. The covalent cross-linking is responsible for its stable mechanical structure. The combination of physical and chemical cross-linking contributes to a novel hydrogel with efficient self-healing ability (80% mechanical recovery in 6 h), high tensile strength (0.109 MPa), and ultrastretchability (2550%), which are highly desirable properties and are superior to previously reported tough and self-healing hydrogels for wound dressing applications. More remarkably, due to plenty of catechol groups on the OSA-DA chains, the hydrogel has unique cell affinity and tissue adhesiveness. Moreover, we demonstrate the practical utility of our fabricated hydrogel via both in vivo and in vitro experiments.

中文翻译：

用于伤口敷料的超韧，自愈和组织粘合水凝胶

用于伤口敷料的潜在用途的水凝胶应具有多种特殊性能，例如有效的自我修复能力和机械韧性，以修复肌肉和皮肤损伤。另外，在实际应用中，水凝胶与伤口组织整合还必须具有出色的细胞亲和力和组织粘附性。本文中，制备了具有优异的细胞亲和力和组织粘附性的超韧和自修复水凝胶。水凝胶的自我修复能力是通过多巴胺接枝的氧化海藻酸钠（OSA-DA）和聚丙烯酰胺（PAM）链之间的氢键和动态席夫（Schiff）交联获得的。共价交联是其稳定的机械结构的原因。物理和化学交联相结合，构成了一种新型水凝胶，具有高效的自修复能力（6小时内机械回复率达80％），高拉伸强度（0.109 MPa）和超拉伸性（2550％），这些都是非常理想的性能并且优于以前报道的用于伤口敷料的坚韧和自修复水凝胶。更显着的是，由于OSA-DA链上有大量的儿茶酚基团，因此水凝胶具有独特的细胞亲和力和组织粘附性。此外，我们通过两种方法展示了我们制备的水凝胶的实用性更显着的是，由于OSA-DA链上有大量的儿茶酚基团，因此水凝胶具有独特的细胞亲和力和组织粘附性。此外，我们通过两种方法展示了我们制备的水凝胶的实用性更显着的是，由于OSA-DA链上有大量的儿茶酚基团，因此水凝胶具有独特的细胞亲和力和组织粘附性。此外，我们通过两种方法展示了我们制备的水凝胶的实用性体内和体外实验。

更新日期：2018-09-11

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