Homeostatic synaptic plasticity as a metaplasticity mechanism - a molecular and cellular perspective.,Current Opinion in Neurobiology

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Homeostatic synaptic plasticity as a metaplasticity mechanism - a molecular and cellular perspective.
Current Opinion in Neurobiology ( IF 4.8 ) Pub Date : 2018-09-11 , DOI: 10.1016/j.conb.2018.08.010
Jie Li ₁ , Esther Park ₁ , Lei R Zhong ₁ , Lu Chen ₁

Affiliation

The molecular mechanisms underlying various types of synaptic plasticity are historically regarded as separate processes involved in independent cellular events. However, recent progress in our molecular understanding of Hebbian and homeostatic synaptic plasticity supports the observation that these two types of plasticity share common cellular events, and are often altered together in neurological diseases. Here, we discuss the emerging concept of homeostatic synaptic plasticity as a metaplasticity mechanism with a focus on cellular signaling processes that enable a direct interaction between Hebbian and homeostatic plasticity. We also identify distinct and shared molecular players involved in these cellular processes that may be explored experimentally in future studies to test the hypothesis that homeostatic synaptic plasticity serves as a metaplasticity mechanism to integrate changes in neuronal activity and support optimal Hebbian learning.

中文翻译：

稳态突触可塑性作为一种化塑性机制——分子和细胞的视角。

历史上，各种类型的突触可塑性背后的分子机制被认为是涉及独立细胞事件的单独过程。然而，我们对赫布和稳态突触可塑性的分子理解的最新进展支持了这样的观察：这两种类型的可塑性具有共同的细胞事件，并且在神经系统疾病中经常一起改变。在这里，我们讨论稳态突触可塑性作为一种化塑性机制的新兴概念，重点关注能够实现赫布和稳态可塑性之间直接相互作用的细胞信号传导过程。我们还确定了参与这些细胞过程的独特和共享的分子参与者，可以在未来的研究中通过实验探索这些参与者，以检验稳态突触可塑性作为一种化塑性机制来整合神经元活动变化并支持最佳赫布学习的假设。

更新日期：2018-09-11

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