Application of Isothermal Nucleic Acid Signal Amplification in the Detection of Hepatocellular Carcinoma-Associated MicroRNA.,ChemPlusChem

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Application of Isothermal Nucleic Acid Signal Amplification in the Detection of Hepatocellular Carcinoma-Associated MicroRNA.
ChemPlusChem ( IF 3.0 ) Pub Date : 2018-10-05 , DOI: 10.1002/cplu.201800382
Dongsheng Mao ₁ , Hong Chen ₁ , Yingying Tang ₁ , Jingwen Li _{1,

2} , Ya Cao ₁ , Jing Zhao ₁

Affiliation

Hepatocellular carcinoma (HCC) is a common type of malignant tumor with high incidence and mortality, and is the third leading cause of cancer-related death in human. High-precision detection of tumor markers, such as microRNA (miRNA), is expected to contribute to the early diagnosis of HCC as well as improve the survival rate of HCC patients. In recent years, great effort has been made to develop different methods to detect HCC-associated miRNA, in which signal amplification strategies are incorporated to realize high sensitivity. Among them, isothermal nucleic acid signal amplification is an emerging signal amplification technology which has the advantages of high amplification efficiency, good reproducibility, and easy operation for real-time analysis. Herein, we provide an overview of the advances in the application of isothermal nucleic acid signal amplification in HCC-associated miRNA detection by highlighting several representative works in recent years.

中文翻译：

等温核酸信号扩增在肝细胞癌相关微小RNA检测中的应用。

肝细胞癌（HCC）是一种常见的恶性肿瘤，具有很高的发病率和死亡率，并且是人类癌症相关死亡的第三大主要原因。高精度检测肿瘤标志物，如microRNA（miRNA），有望有助于HCC的早期诊断并提高HCC患者的存活率。近年来，人们大力开发了多种检测HCC相关miRNA的方法，其中并入了信号放大策略以实现高灵敏度。其中，等温核酸信号扩增是一种新兴的信号扩增技术，具有扩增效率高，重现性好，实时分析操作简便等优点。在此处，

更新日期：2018-10-05

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