FeCl3-promoted tandem 1,4-conjugate addition/6-endo-dig cyclization/oxidation of propargylamines and benzoylacetonitriles/malononitriles: direct access to functionalized 2-aryl-4H-chromenes,Organic & Biomolecular Chemistry

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FeCl3-promoted tandem 1,4-conjugate addition/6-endo-dig cyclization/oxidation of propargylamines and benzoylacetonitriles/malononitriles: direct access to functionalized 2-aryl-4H-chromenes
Organic & Biomolecular Chemistry ( IF 2.9 ) Pub Date : 2018-09-08 , DOI: 10.1039/c8ob01927d
Xinwei He _{1,

2,

3,

4,

5} , Hui Wang _{1,

2,

3,

4,

5} , Xiaoting Cai _{1,

2,

3,

4,

5} , Qianqian Li _{1,

2,

3,

4,

5} , Jiajia Tao _{1,

2,

3,

4,

5} , Yongjia Shang _{1,

2,

3,

4,

5}

Affiliation

An efficient and concise procedure has been developed for the synthesis of functionalized 2-aryl-4H-chromenes based on a tandem reaction of propargylamines and benzoylacetonitriles/malononitriles in the presence of FeCl₃ as an environmentally friendly promoter. This reaction involves a highly efficient tandem sequence consisting of 1,4-conjugate addition, 6-endo-dig cyclization, and oxidation. This protocol tolerates a variety of functional groups, thereby providing a practical and efficient method for the fabrication of 2-aryl-4H-chromene skeletons.

中文翻译：

FeCl ₃促进的串联1,4-共轭加成/ 6-炔丙基胺和苯甲酰基乙腈/丙二腈的内挖环化/氧化：直接获得功能化的2-芳基-4 H-苯甲基

一种有效和简洁的方法已经为官能化的2-芳基4的合成已经开发ħ -chromenes基于炔丙胺和benzoylacetonitriles的串联反应/丙二腈在的FeCl存在₃作为环保型启动子。该反应涉及由1，4-缀合物加成，6-内-挖-环化和氧化组成的高效串联序列。该方案可耐受多种官能团，从而为制造2-芳基-4 H-色烯骨架提供了一种实用而有效的方法。

更新日期：2018-10-11

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