Newly endocytosed integral cell surface proteins are typically either directed for degradation or subjected to recycling back to the plasma membrane. The sorting of integral cell surface proteins, including signalling receptors, nutrient transporters, ion channels, adhesion molecules and polarity markers, within the endolysosomal network for recycling is increasingly recognized as an essential feature in regulating the complexities of physiology at the cell, tissue and organism levels. Historically, endocytic recycling has been regarded as a relatively passive process, where the majority of internalized integral proteins are recycled via a nonspecific sequence-independent ‘bulk membrane flow’ pathway. Recent work has increasingly challenged this view. The discovery of sequence-specific sorting motifs and the identification of cargo adaptors and associated coat complexes have begun to uncover the highly orchestrated nature of endosomal cargo recycling, thereby providing new insight into the function and (patho)physiology of this process.

新内吞的整合细胞表面蛋白通常要么被直接降解，要么被回收回到质膜。在内溶酶体网络内对完整细胞表面蛋白（包括信号受体、营养转运蛋白、离子通道、粘附分子和极性标记物）进行分类以进行回收，越来越被认为是调节细胞、组织和生物体生理学复杂性的一个重要特征水平。从历史上看，内吞回收被认为是一个相对被动的过程，其中大多数内化的整合蛋白通过非特异性序列独立的“体膜流”途径回收。最近的工作越来越多地挑战了这一观点。序列特异性分选基序的发现以及货物接头和相关外壳复合物的识别已经开始揭示内体货物回收的高度精心安排的性质，从而为该过程的功能和（病理）生理学提供新的见解。