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Loss of sterol metabolic homeostasis triggers inflammasomes - how and why.
Current Opinion in Immunology ( IF 6.6 ) Pub Date : 2018-08-29 , DOI: 10.1016/j.coi.2018.08.001 Eric V Dang 1 , Jason G Cyster 2
Current Opinion in Immunology ( IF 6.6 ) Pub Date : 2018-08-29 , DOI: 10.1016/j.coi.2018.08.001 Eric V Dang 1 , Jason G Cyster 2
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Proper regulation of sterol biosynthesis is critical for eukaryotic cellular homeostasis. Cholesterol and isoprenoids serve key roles in eukaryotic cells by regulating membrane fluidity and correct localization of proteins. It is becoming increasingly appreciated that dysregulated sterol metabolism engages pathways that lead to inflammation. Of particular importance are inflammasomes, which are multiplatform protein complexes that activate caspase-1 in order to process the pro-inflammatory and pyrogenic cytokines IL-1β and IL-18. In this review, we highlight recent research that links altered sterol biosynthetic pathway activity to inflammasome activation. We discuss how clues from human genetics have led to new insights into how alterations in isoprenoid biosynthesis connect to inflammation. We also discuss new mechanisms that show how macrophage cholesterol buildup can lead to inflammasome activation.
中文翻译：
甾醇代谢稳态的丧失会触发炎症小体——如何以及为什么。
甾醇生物合成的适当调节对于真核细胞稳态至关重要。胆固醇和类异戊二烯通过调节膜流动性和蛋白质的正确定位在真核细胞中发挥关键作用。人们越来越认识到，失调的甾醇代谢参与了导致炎症的途径。特别重要的是炎症小体，它是多平台蛋白复合物，可激活 caspase-1 以处理促炎和致热细胞因子 IL-1β 和 IL-18。在这篇综述中，我们重点介绍了最近将改变的甾醇生物合成途径活性与炎症小体激活联系起来的研究。我们讨论了来自人类遗传学的线索如何导致对类异戊二烯生物合成的改变如何与炎症相关联的新见解。
更新日期：2018-08-29
中文翻译：
甾醇代谢稳态的丧失会触发炎症小体——如何以及为什么。
甾醇生物合成的适当调节对于真核细胞稳态至关重要。胆固醇和类异戊二烯通过调节膜流动性和蛋白质的正确定位在真核细胞中发挥关键作用。人们越来越认识到，失调的甾醇代谢参与了导致炎症的途径。特别重要的是炎症小体，它是多平台蛋白复合物，可激活 caspase-1 以处理促炎和致热细胞因子 IL-1β 和 IL-18。在这篇综述中，我们重点介绍了最近将改变的甾醇生物合成途径活性与炎症小体激活联系起来的研究。我们讨论了来自人类遗传学的线索如何导致对类异戊二烯生物合成的改变如何与炎症相关联的新见解。
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